Angiogenesis Models - AngioMouse™

Features                                                                                                                                    Examples

Visualization of tumor vessels using GFP tumor expression Intravital imaging of tumor vessels Whole-body imaging of tumor vessels Quantitation of vessel density Real-time angiogenesis studies Angiogenesis drug discovery and evalation Orthotopic models of all tumor types

Whole-body image of vessels in PC-3-GFP human prostate cancer in nude mouse.   Intravital image of ANIP-973-GFP human lung cancer in nude mouse.   Whole-body image of Lewis lung-GFP mouse carcinoma in nude mouse.

1.      Yang, M., Baranov, E., Li, X-M., Wang, J-W., Jiang, P., Li, L., Moossa, A.R., Penman, S., Hoffman, R.M.  Whole‑body and intravital optical imaging of angiogenesis in orthotopically implanted tumors.  Proc. Natl. Acad. Sci. USA 98, 2616-2621, 2001.