Bladder cancer models  

Features

  • Orthotopic transplantation of intact tissue

  • Metastatic sites

                   lymph nodes

                   liver

                   lung

                   pancreas

                   spleen

                   diaphragm 

                   omentum

  • Green Fluorescent Protein expression

Example

KU-7-GFP human bladder carcinoma growing on nude mouse bladder

  1. Fu, X., Theodorescu, D., Kerbel, R.S., and Hoffman, R.M.  Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice.  Int. J. Cancer 49, 938-939, 1991.[PDF] 

  2. Fu, X., and Hoffman, R.M.  Human RT-4 bladder carcinoma is highly metastatic in nude mice and comparable to ras-H-transformed RT-4 when orthotopically onplanted as histologically intact tissue.  Int. J. Cancer 51, 989-991, 1992.[PDF]       

  3. Chang, S-G., Kim, J.I., Jung, J-C., Rho, Y-S., Lee, K-T., An, Z., Wang, X., and Hoffman, R.M.  Antimetastatic activity of the new platinum analog {Pt(cis-dach)(DPPE)×2NO3} in a metastatic model of human bladder cancer.  Anticancer Res. 17, 3239-3242, 1997.[PDF] 

  4. Zhou, J-H., Rosser, C.J., Tanaka, M., Yang, M., Baranov, E., Hoffman, R.M., Benedict, W.F. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression.  Cancer Gene Therapy 9, 681-686, 2002.[PDF]