Breast cancer models  

Features

  • Orthotopic transplantation of intact tissue 

  • Metastatic sites

                   lymph nodes

                   liver

                   lung

                  skeleton 

  • Estrogen-dependent 

  • Estrogen-independent 

  • Green Fluorescent Protein expression 

  • Red Fluorescent Protein expression

Example

MX-1-GFP and –RFP breast carcinoma growing on mammary fat pads of SCID mouse. Whole-body image.

  1. Fu, X., Le, P., and Hoffman, R.M.  A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.  Anticancer Res. 13, 901-904, 1993.[PDF] 

  2. Kubota, T., Inoue, S., Furukawa, T., Ishibiki, K., Kitajima, M., Kawamura, E., and Hoffman, R.M.  Similarity of serum – Tumor pharmacokinetics of antitumor agents in man and nude mice.  Anticancer Res. 13, 1481-1484, 1993.[PDF] 

  3.  Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang, P., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable metastatic model of human breast cancer. Clinical & Experimental Metastasis, 19, 347-350, 2002. [PDF]

  4. John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer Res. 9, 3808-3814, 2003 [PDF]

  5. Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi, V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from non-metastatic breast tumors revealed by labeling with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814, 2003. [PDF]