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Chang, S-G., Kim, J.I., Jung, J-C., Rho,
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Zhou, J-H., Rosser, C.J., Tanaka, M.,
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Fu, X., Le, P., and Hoffman, R.M. A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. Anticancer Res. 13, 901-904, 1993. [PDF]
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John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer Res. 9, 3808-3814, 2003 [PDF]
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Furukawa,
T., Kubota, T., Watanabe, M., Kuo, T.H., Kase, S., Saikawa, Y., Tanino, H.,
Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M.
Immunochemotherapy prevents human colon cancer metastasis after
orthotopic onplantation of histologically-intact tumor tissue in nude mice.
Anticancer Res. 13, 287-291,
1993.
Kuo,
T-H., Kubota, T., Watanabe, M., Furukawa, T., Teramoto, T., Ishibiki, K.,
Kitajima, M., and Hoffman, R.M. Early
resection of primary orthotopically-growing human colon tumor in nude mouse
prevents liver metastasis: further evidence for patient-like hematogenous
metastatic route. Anticancer Res. 13,
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Furukawa,
T., Kubota, T., Watanabe, M., Kuo, T-H., Nishibori, H., Kase, S., Saikawa, Y.,
Tanino, H., Teramoto, T., Ishibiki, K., and Kitajima, M.
A metastatic model of human colon cancer constructed using cecal
implantation of cancer tissue in nude mice.
Jpn. J. Surg. 23, 420-423, 1993.
Wang, X.,
Fu, X., Brown, P.D., Crimmin, M.J., and Hoffman, R.M.
Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human
colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Cancer Res. 54, 4726-4728,
1994.
Togo, S.,
Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M.
“Seed” to “soil” is a return trip in metastasis. Anticancer Res. 15,
791-794, 1995.
Togo, S.,
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Host organ specifically determines cancer progression.
Cancer Res. 55, 681-684, 1995.
Kuo,
T-H., Kubota, T., Watanbe, M., Furukawa, T., Teramoto, T., Ishibiki, K.,
Kitajimi, M., Moossa, A.R., Penman, S., Hoffman, R.M. Liver colonization competence governs colon cancer
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Togo, S., Wang, X., Shimada, H., Moossa, A.R., and Hoffman, R.M. Cancer seed and soil can be highly selective: Human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis. Anticancer Res. 15, 795-798, 1995. [PDF]
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Clinical & Experimental Metastasis 15,
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Cimetidine: An inhibitor or promoter of tumor growth?
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Rho,
Y-S., Lee, K-T., Jung, J-C., Yoon, C., An, Z., Hoffman, R.M., and Chang, S-G.
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Minimal liver resection strongly stimulates the growth of human colon
cancer in the liver of nude mice. Clinical
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Rashidi,
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A nude mouse model of massive liver and lymph node metastasis of human
colon cancer. Anticancer Res. 20,
715-722, 2000.
Rashidi,
B., An, Z., Sun, F-X., Moossa, A.R., and Hoffman, R.M.
Antimetastatic intraoperative chemotherapy of human colon tumors in the
livers of nude mice. Clinical Cancer Res. 6,
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Rashidi,
B., Gamagami, R., Sasson, A., Sun, F-X., Geller, J., Moossa, A.R., and Hoffman,
R.M. An orthotopic mouse model of
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Gene Therapy
Miki, K., Xu, M., An, Z., Wang, X.,
Yang, M., Al-Refaie, W., Sun, X., Baranov, E., Tan, Y., Chishima, T., Shimada,
H., Moossa, A.R., Hoffman, R.M. Survival
efficacy of the combination of the methioninase gene and methioninase in a lung
cancer orthotopic model. Cancer
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Miki, K., Al-Refaie, W., Xu, M., Jiang,
P., Tan, Y., Bouvet, M., Zhao, M., Gupta, A., Chishima, T., Shimada, H.,
Makuuchi, M., Moossa, A.R., and Hoffman, R.M.
Methioninase gene therapy of human cancer cells is synergistic with
recombinant methioninase treatment. Cancer
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Hasegawa, S., Yang, M., Chishima, T.,
Shimada, H., Moossa, A.R., Hoffman, R.M. In
vivo tumor delivery of the green fluorescent protein gene to report future
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Djeha, A.H., Thomson, T.A., Leung, H.,
Searle, P.F., Young, L.S., Kerr, D.J., Harris, P.A., Mountain, A., and Wrighton,
C.J. Combined adenovirus-mediated
nitroreductase gene delivery and CB1954 treatment: A well-tolerated therapy for
established solid tumors. Molecular
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S.S., Jakubczak, J.L., Stewart, D.A., Skripchenko, Y., Forry-Schaudies, S.,
Wood, J., Schnell, C., and Hallenbeck, P.L.
Antiangiogenic gene therapy for cancer via systemic administration of
adenoviral vectors expressing secretable endostatin. Human Gene Therapy 11, 1983-1996, 2000.
Miki, K, Xu, M., Gupta, A., Ba, Y.,
Tan, Y., Al-Refaie, W., Bouvet, M., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.
Methioninase cancer gene therapy with selenomethionine as suicide prodrug
substrate. Cancer Research 61,
6805-6810, 2001.
Kamiyama, M., Ichikawa, Y., Ishikawa,
T., Chishima, T., Hasegawa, S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y.,
Mitsuhashi, M., Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H.
VEGF receptor antisense therapy inhibits angiogenesis and peritoneal
dissemination of human gastric cancer in nude mice. Cancer Gene Therapy 9,
197-201, 2002.
Pirocanac, E.C., Nassirpour, R., Yang,
M., Wang, J-W., Nardin, S.R., Gu, J., Fang, B., Moossa, A.R., Hoffman, R.M., and
Bouvet, M. Bax-induction
gene therapy of pancreatic cancer. J.
Surg. Res. 106, 346-351, 2002.
Katz, M.H., Spivak, D.E., Takimoto, S., Fang, B., Burton, D.W., Moosa, A.R., Hoffman, R.M., Bouvet, M. Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter. Annals of Surgical Oncology, 10(7): 762-772, 2003. [PDF]
An, Z., Jiang, P., Wang, X., Moossa, A.R.,
and Hoffman, R.M. Development of a high metastatic orthotopic model of human
renal cell carcinoma in nude mice: Benefits of fragment implantation compared to
cell-suspension injection. Clinical
& Experimental Metastasis 17, 265-270, 1999.
Wang, X.,
Fu, X., and Hoffman, R.M. A new
patient-like metastatic model of human lung cancer constructed orthotopically
with intact tissue via thoracotomy in immunodeficient mice.
Int. J. Cancer 51, 992-995, 1992.
Kuo,
T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Nishibori,
K., Saikawa, Y., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M.
Orthotopic reconstitution of human small-cell lung carcinoma after
intravenous transplantation in SCID mice. Anticancer
Res. 12, 1407-1410, 1992.[PDF]
Wang, X.,
Fu, X., and Hoffman, R.M. A
patient-like metastasizing model of human lung adenocarcinoma constructed via
thoracotomy in nude mice. Anticancer
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Wang, X.,
Fu, X., Kubota, T., and Hoffman, R.M. A
new patient-like metastatic model of human small-cell lung cancer constructed
orthotopically with intact tissue via thoracotomy in nude mice.
Anticancer Res. 12, 1403-1406,
1992.
Kuo,
T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Saikawa, Y.,
Ishibiki, K., Kitajima, M., and Hoffman, R.M. Site-specific chemosensitivity of human small-cell lung
carcinoma growing orthotopically compared to subcutaneously in SCID mice: the
importance of orthotopic models to obtain relevant drug evaluation data.
Anticancer Res. 13, 627-630, 1993.
Astoul,
P., Wang, X., and Hoffman, R.M. "Patient-like"
nude- and SCID-mouse models of human lung and pleural cancer (Review).
Int. J. Oncology 3, 713-718, 1993.
Astoul,
P., Colt, H.G., Wang, X., and Hoffman, R.M.
A “patient-like” nude mouse model of parietal pleural human lung
adenocarcinoma. Anticancer Res. 14,
85-92, 1994.
Astoul,
P., Colt, H.G., Wang, X., Boutin, C. and Hoffman, R.M.
A “patient-like” nude mouse metastatic model of
advanced human pleural cancer. Journal
of Cellular Biochemistry 56, 9-15,
1994.
Astoul, P., Wang, X., Colt, H.G., Boutin, C., and Hoffman, R.M. A patient-like human malignant pleural mesothelioma nude-mouse model. Oncology Reports 3, 483-487, 1996.[PDF]
Colt, H.G.,
Astoul, P., Wang, X., Yi, E.S., Boutin, C., and Hoffman, R.M.
Clinical course of human epithelial-type malignant pleural mesothelioma
replicated in an orthotopic-transplant nude mouse model.
Anticancer Res. 16, 633-640,
1996.
An, Z.,
Wang, X., Astoul, P., Danays, T., Moossa, A.R., and Hoffman, R.M.
Interferon gamma is highly effective against orthotopically-implanted
human pleural adenocarcinoma in nude mice.
Anticancer Res. 16, 2545-2551, 1996.
Olbina,
G., Cieslak, D., Ruzdijic, S., Esler, C., An, Z., Wang, X., Hoffman, R.,
Seifert, W., and Pietrzkowski, Z. Reversible inhibition of IL-8 receptor B mRNA
expression and proliferation in non-small cell lung cancer by antisense
oligonucleotides. Anticancer Res. 16,
3525-3530, 1996.
Yang, M.,
Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima, T., Shimada, H., Moossa,
A.R., and Hoffman, R.M. Widespread
skeletal metastatic potential of human lung cancer revealed by green fluorescent
protein expression. Cancer Res. 58,
4217-4221, 1998.
Rashidi,
B., Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X., Moossa, A.R., and
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Lewis lung carcinoma orthotopic green fluorescent protein model.
Clinical & Experimental Metastasis 18,
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Hoffman,
Robert M. Metastatic Mouse Models
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and Reviews. Totowa, NJ: Humana
Press, 457-464, 2002.
Yamamoto,
N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman,
R.M. Real-time GFP imaging of
spontaneous HT-1080 fibrosarcoma lung metastases. Clin. Exp. Metastasis 20,
181-185, 2003.
Sun, F.X., Tang, Z.Y., Liu, K.D., Ye,
S.L., Xue, Q., Gao, D.M., and Ma, Z.C. Establishment
of a metastatic model of human hepatocellular carcinoma in nude mice via
orthotopic implantation of histologically intact tissues. Int. J. Cancer 66,
239-243, 1996.
Sun, F-X., Tang, Z-Y., Liu, K-D., Xue,
Q., Gao, D-M., Yu, Y-Q., Zhou, X-D., Ma, Z-C.
Metastatic models of human liver cancer in nude mice orthotopically
constructed by using histologically intact patient specimens.
J. Cancer Res. Clin. Oncol. 122,
397-402, 1996.
Rashidi, B., An, Z., Sun, F-X, Li,
X-M., Tang, Z.Y., Moossa, A.R., and Hoffman, R.M.
Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis of human
hepatocellular carcinoma in nude mice. Int.
J. Cancer 91, 231-235, 2001.
Wu, M., Mazarchuk, R., Chaudhary, N.D., Spernyak, J., Veith, J., Pera, P., Greco, W., Hoffman, R.M., Kobayashi, T., and Bernacki, R.J. High Resolution Magnetic Resonance Imaging of the Efficacy of the Cytosine Analogue 1-[2-C-Cyano-2-deoxy-b-D-arabino-pentofuranosyl]-N4 - palmitoyl Cytosine (CS-682) in a Liver-Metastasis Athymic Nude Mouse Model. Cancer Res. 63, 2477-2482, 2003.[PDF]
Fu, X., and Hoffman, R.M. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Res. 13, 283-286, 1993. [PDF]
Astoul, P., Colt, H.G., Wang, X., and
Hoffman, R.M. Metastatic human
pleural ovarian cancer model constructed by orthotopic implantation of fresh
histologically-intact patient carcinoma in nude mice. Anticancer Res. 13,
1999-2002, 1993.[PDF]
Kiguchi, K., Kubota, T., Aoki, D.,
Udagawa, Y., Yamanouchi, S., Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R.,
and Hoffman, R.M. A patient-like
orthotopic implantation nude mouse model of highly metastatic human ovarian
cancer. Clinical & Experimental Metastasis
16, 751-756, 1998.
Fu, X.,
Guadagni, F., and Hoffman, R.M. A
metastatic nude-mouse model of human pancreatic cancer constructed
orthotopically from histologically intact patient specimens.
Proc. Natl. Acad. Sci. USA 89,
5645-5649, 1992.
Furukawa,
T., Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M.
A novel "patient-like" treatment model of human pancreatic
cancer constructed using orthotopic transplantation of histologically intact
human tumor tissue in nude mice. Cancer
Res. 53, 3070-3072, 1993.
An, Z.,
Wang, X., Kubota, T., Moossa, A.R., Hoffman, R.M. A clinical nude mouse metastatic model for highly malignant
human pancreatic cancer. Anticancer
Res. 16, 627-631, 1996.
Tomikawa,
M., Kubota, T., Matsuzaki, S.W., Takahasi, S., Kitajima, M., Moossa, A.R., and
Hoffman, R.M. Mitomycin C and
cisplatin increase survival in a human pancreatic cancer metastatic model.
Anticancer Res. 17, 3623-3626, 1997.
Bouvet,
M., Yang, M., Nardin, S., Wang, X., Jiang, P., Baranov, E., Moossa, A.R.,
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metastatic targeting of human pancreatic tumors in orthotopic models.
Clinical & Experimental Metastasis 18,
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Lee,
N.C., Bouvet, M., Nardin, S., Jiang, P., Baranov, E., Rashidi, B., Yang, M.,
Wang, X., Moossa, A.R., and Hoffman, R.M. Antimetastatic
efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model.
Clinical & Experimental Metastasis 18, 379-384, 2001.
Bouvet,
M., Wang, J-W., Nardin, S.R., Nassirpour, R., Yang, M., Baranov, E., Jiang, P.,
Moossa, A.R., and Hoffman, R.M. Real-time
optical imaging of primary tumor growth and multiple metastatic events in a
pancreatic cancer orthotopic model. Cancer
Research 62, 1534-1540, 2002.
Bouvet,
M., Nardin, S.R., Burton, D.W., Lee, N.C., Yang, M., Wang, X., Baranov, E.,
Behling, C., Moossa, A.R., Hoffman, R.M., and Deftos L.J.
Parathyroid hormone-related protein as a novel tumor marker in pancreatic
adenocarcinoma. Pancreas 24,
284-290, 2002.
Sun,
F-X., Tohgo, A., Bouvet, M., Yagi, S., Nassirpour, R., Moossa, A.R., and
Hoffman, R.M. Efficacy of
camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in
an orthotopic metastatic model. Cancer
Research 63, 80-85, 2003.
Katz, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M., Bouvet, M. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J.Surg. Res. 113, 151-160, 2003.[PDF]
Katz, M.H., Bouvet, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res. 63, 5521-5525, 2003.[PDF]
Fu, X., Herrera, H., and Hoffman, R.M.
Orthotopic growth and metastasis of human prostate carcinoma in nude mice
after transplantation of histologically intact tissue.
Int. J. Cancer 52, 987-990,
1992.
An, Z., Wang, X., Geller, J., Moossa,
A.R., and Hoffman, R.M. Surgical
orthotopic implantation allows high lung and lymph node metastatic expression of
human prostate carcinoma cell line PC-
3 in nude mice. The Prostate
34, 169-174, 1998.
Yang, M., Jiang, P., Sun, F.X.,
Hasegawa, S., Baranov, E., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman,
R.M. A fluorescent orthotopic bone
metastasis model of human prostate cancer.
Cancer Res. 59, 781-786, 1999.
Wang, X., An, Z., Geller, J., and
Hoffman, R.M. High malignancy
orthotopic nude mouse model of human prostate cancer LNCaP.
The Prostate 39, 182-186,
1999.
Glinskii, A.B., Smith, B.A., Jiang, P., Li, X-M., Yang, M., Hoffman, R.M., Glinsky, G.V. Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res. 63, 4239-4243, 2003.[PDF]
Glinsky, G.V., Glinskii, A.B., Stephenson A.J., Hoffman, R.M., Gerald W.L. Gene expression profiling predicts clinical outcome of prostate cancer. J. Clin. Invest. 113, 913-923, 2004 [PDF]
Sarcoma
Yamamoto, N., Yang, M., Jiang, P., Xu,
M.,
Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.
Real-time imaging of individual color-coded metastatic colonies in
vivo. Clin. Exp. Metastasis 20(7),
633-638, 2003.[PDF]
Stomach
Furukawa, T., Fu, X., Kubota, T.,
Watanabe, M., Kitajima, M., and Hoffman, R.M. Nude mouse metastatic models of
human stomach cancer constructed using orthotopic implantation of histologically
intact tissue. Cancer Res. 53,
1204-1208, 1993.
Furukawa, T., Kubota, T., Watanabe, M.,
Kitajima, M., and Hoffman, R.M. Orthotopic
transplantation of histologically intact clinical specimens of stomach cancer to
nude mice: Correlation of metastatic sites in mouse and individual patient
donors. Int. J. Cancer 53,
608-612, 1993.
Furukawa, T., Kubota, T., Watanabe, M.,
Kuo, T-H., Kitajima, M., and Hoffman, R.M.
Differential chemosensitivity of local and metastatic human gastric
cancer after orthotopic transplantation of histologically intact tumor tissue in
nude mice. Int. J. Cancer 54,
397-401, 1993.
Inada, T., Ichikawa, A., Kubota, T.,
Ogata, Y., Moossa, A.R., and Hoffman, R.M.
5-FU-induced apoptosis correlates with efficacy against human gastric and
colon cancer xenografts in nude mice. Anticancer
Res. 17, 1965-1971, 1997.
Hasegawa, S., Yang, M., Chishima, T.,
Shimada, H., Moossa, A.R., Hoffman, R.M. In
vivo tumor delivery of the green fluorescent protein gene to report future
occurrence of metastasis. Cancer Gene Therapy 7,
1336-1340, 2000.
Kamiyama, M., Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa, S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M., Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H. VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Therapy 9, 197-201, 2002.
Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A.R., and Hoffman, R.M. Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res. 57, 2042-2047, 1997.[PDF]
Chishima, T., Miyagi, Y., Wang, X.,
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process by green fluorescent protein expression.
Clinical & Experimental Metastasis 15, 547-552, 1997.
Chishima, T., Miyagi, Y., Wang, X.,
Tan, Y., Shimada, H., Moossa, A.R., and Hoffman, R.M.
Visualization of the metastatic process by green fluorescent protein
expression. Anticancer Res. 17,
2377-2384, 1997.
Chishima, T., Yang, M., Miyagi, Y., Li, L., Tan, Y., Baranov, E., Shimada, H., Moossa, A.R., Penman, S., and Hoffman, R.M. Governing step of metastasis visualized in vitro. Proc. Natl. Acad. Sci. USA 94, 11573-11576, 1997. [PDF]
Chishima, T., Miyagi, Y., Li, L., Tan,
Y., Baranov, E., Yang, M., Shimada, H., Moossa, A.R., and Hoffman, R.M.
The use of histoculture and green fluorescent protein to visualize tumor
cell host interaction. In Vitro Cell. Dev. Biol. 33,
745-747, 1997.
Yang, M., Hasegawa, S., Jiang, P.,
Wang, X., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M.
Widespread skeletal metastatic potential of human lung cancer revealed by
green fluorescent protein expression. Cancer
Res. 58, 4217-4221, 1998.
Yang, M., Jiang, P., Sun, F.X., Hasegawa, S., Baranov, E., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M. A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res. 59, 781-786, 1999.[PDF]
Hoffman, R.M.
Orthotopic transplant mouse models with green fluorescent
protein-expressing cancer cells to visualize metastasis and angiogenesis.
Cancer and Metastasis Reviews 17,
271-277, 1999.
Hoffman, R.M.
Green fluorescent protein to visualize cancer progression and metastasis.
Methods in Enzymology, Green Fluorescent Protein, Vol. 302. Ed: P.
Michael Conn, Academic Press, San Diego, pp. 20-31, 1999.
Naumov, G.N., Wilson, S.M., MacDonald,
I.C., Schmidt, E.E., Morris, V.L., Groom, A.C., Hoffman, R.M., and Chambers, A.F.
Cellular expression of green fluorescent protein, coupled with
high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis.
Journal of Cell Science 112,
1835-1842, 1999.
Yang, M., Chishima, T., Baranov, E.,
Shimada, H., Moossa, A.R., and Hoffman, R.M.
Green fluorescent protein: A new light to visualize metastasis and
angiogenesis in cancer. Proc. of
SPIE Conference on Molecular Imaging: Reporters, Dyes, Markers and
Instrumentation 3500, 117-124, 1999.
Yang, M., Jiang, P., An, Z., Baranov,
E., Li, L., Hasegawa, S., Al-Tuwaijri, M., Chishima, T., Shimada, H., Moossa,
A.R., Hoffman, R.M. Genetically
fluorescent melanoma bone and organ metastasis models.
Clinical Cancer Res. 5,
3549-3559, 1999.
Yang, M., Chishima, T., Wang, X.,
Baranov, E., Shimada, H., Moossa, A.R., and Hoffman, R.M. Multi-organ metastatic
capability of Chinese hamster ovary cells revealed by green fluorescent protein
(GFP) expression. Clinical &
Experimental Metastasis, 17, 417-422,
1999.
Hoffman, R.M.
Visualization of metastasis in orthotopic mouse models with green
fluorescent protein. In: Relevance of
Tumor Models in Anticancer Drugs Development.
Eds.: Fiebig, H.H., Burger, A.M., Kluwver Academic Publishers, Dordrecht,
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F-X., Li, X-M., Li, L., Hasegawa, S., Bouvet, M., Al-Tuwaijri, M., Chishima, T.,
Shimada, H., Moossa, A.R., Penman, S., Hoffman, R.M. Whole-body optical imaging
of green fluorescent protein-expressing tumors and metastases. Proc. Natl. Acad. Sci. USA 97,
1206-1211, 2000.
Dove, A. Illuminating cancer models.
Nature Biotechnology 18, 261, 2000.
Hoffman, R.M.
Correspondence re: Initial stages of tumor cell-induced angiogenesis:
Evaluation via skin window chambers in rodent models. Journal of the National
Cancer Institute 92, 1445, 2000.
Yang, M., Baranov, E., Shimada, H.,
Moossa, A.R., and Hoffman, R.M. External
optical imaging freely-moving mice with green fluorescent protein-expressing
metastatic tumors. Proc. of SPIE
Conference, 3921, 256-259, 2000.
Corrigendum, BioFeedback.
Biotechniques 29, 544, September 2000.
Yang, M., Baranov, E., Moossa, A.R.,
Penman, S., Hoffman, R.M. Visualizing
gene expression by whole-body fluorescence imaging.
Proc. Natl. Acad. Sci. USA 97,
12278-12282, 2000.[PDF]
Hasegawa, S., Yang, M., Chishima, T.,
Shimada, H., Moossa, A.R., Hoffman, R.M. In
vivo tumor delivery of the green fluorescent protein gene to report future
occurrence of metastasis. Cancer Gene Therapy 7,
1336-1340, 2000.
Rashidi, B., Yang, M., Jiang, P.,
Baranov, E., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M. A highly metastatic Lewis lung carcinoma orthotopic green
fluorescent protein model. Clinical
& Experimental Metastasis 18,
57-60, 2000.
Bouvet, M., Yang, M., Nardin, S., Wang,
X., Jiang, P., Baranov, E., Moossa, A.R., Hoffman, R.M. Chronologically-specific metastatic targeting of human
pancreatic tumors in orthotopic models. Clinical
& Experimental Metastasis 18,
213-218, 2000.
Yang, M., Baranov, E., Li, X-M., Wang,
J-W., Jiang, P., Li, L., Moossa, A.R., Penman, S., Hoffman, R.M.
Whole‑body and intravital optical imaging of angiogenesis in
orthotopically implanted tumors. Proc. Natl. Acad. Sci. USA 98,
2616-2621, 2001.
Robinson, K.
Imaging system captures whole-body GFP images. Biophotonics International, April,
54-55, 2001.
Pfeifer, A., Kessler, T., Yang, M.,
Baranov, E., Kootstra, N., Cheresh, D.A., Hoffman, R.M., and Verma, I.M.
Transduction of liver cells by lentiviral vectors: Analysis in living
animals. Molecular Therapy 3,
319-322, 2001.
Hoffman, Robert M. Visualization of GFP-expressing tumors and metastasis in
vivo. BioTechniques 30,
1016-1016, 2001.
Hutchinson, E.
Fluorescence imaging of tumour metastasis and angiogenesis.
The Lancet Oncology, 2, 254, 2001.
McCann, J.
Jellyfish protein gives new glow to tumor imaging.
Journal of the National Cancer Institute 93,
976-977, 2001.
Lee, N.C., Bouvet, M., Nardin, S.,
Jiang, P., Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and
Hoffman, R.M. Antimetastatic
efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model.
Clinical & Experimental Metastasis 18,
379-384, 2001.
Hoffman, R.M.
Green Fluorescent Protein for Metastasis Research.
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Vol. II. Analysis of Cell Behavior In
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Zhao,
M., Yang.M., Baranov, E., Wang, X., Penman, S., Moossa, A.R., Hoffman, R.M.
Spatial-temporal imaging of bacterial infection and antibiotic response in
intact animals. Proc. Natl. Acad. Sci. USA 98,
9814-9818, 2001.
Hoffman, R.M.
GFP-Expressing Metastatic-Cancer Mouse Models. In: Teicher, B.,
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Research. Totowa, NJ: Humana Press
Inc., 99-112, 2002.
Kamiyama, M., Ichikawa, Y., Ishikawa,
T., Chishima, T., Hasegawa, S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y.,
Mitsuhashi, M., Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H.
VEGF receptor antisense therapy inhibits angiogenesis and peritoneal
dissemination of human gastric cancer in nude mice. Cancer Gene Therapy 9,
197-201, 2002.
Yang, M., Baranov, E., Wang, J-W.,
Jiang, P., Wang, X., Sun, F-X., Bouvet, M., Moossa, A.R., Penman, S., and
Hoffman, R.M. Direct external
imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on
internal organs in the fluorescent orthotopic model.
Proc. Natl. Acad. Sci. USA 99,
3824-3829, 2002.
Bouvet, M., Wang, J-W., Nardin, S.R.,
Nassirpour, R., Yang, M., Baranov, E., Jiang, P., Moossa, A.R., and Hoffman, R.M.
Real-time optical imaging of primary tumor growth and multiple metastatic
events in a pancreatic cancer orthotopic model.
Cancer Research 62, 1534-1540,
2002.
Hoffman, R.M.
Green fluorescent protein imaging of tumor cells in mice.
Lab Animal 31, 34-41, 2002.
Bouvet, M., Nardin, S.R., Burton, D.W.,
Lee, N.C., Yang, M., Wang, X., Baranov, E., Behling, C., Moossa, A.R., Hoffman,
R.M., and Deftos L.J. Parathyroid
hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma.
Pancreas 24, 284-290, 2002.
Schmitt, C.A., Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M. and Lowe, S.W. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1, 289-298, 2002.[PDF]
Schmitt, C.A., Yang, M., Fridman, J.S., Baranov, E., Hoffman, R.M., and Lowe, S.W. Senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335–346, 2002. [PDF]
Li, X-M., Wang, J-W., An, Z., Yang, M.
Baranov, E., Jiang, P., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically
imageable metastatic model of human breast cancer. Clinical & Experimental
Metastasis, 19, 347-350, 2002.
Hoffman, R.M.
Watching real-time metastasis in
vivo. Trends in Molecular
Medicine, 8(7), 354-355, 2002.
Hoffman, R.M.
Whole-body fluorescence imaging with Green Fluorescence Protein.
In: Hicks, B.W., ed.
Methods in Molecular Biology, Vol. 183: Green Fluorescent Protein:
Applications and Protocols. Totowa,
NJ: Humana Press, 135-148, 2002.
Hoffman, R.M.
In vivo imaging of metastatic
cancer with fluorescent proteins. Journal
of Cell Death and Differentiation 9, 786-789, 2002.
Zhou, J-H., Rosser, C.J., Tanaka, M.,
Yang, M., Baranov, E., Hoffman, R.M., Benedict, W.F. Visualizing superficial
human bladder cancer cell growth in vivo
by green fluorescent protein expression. Cancer
Gene Therapy 9, 681-686, 2002.
Hoffman, R.M.
Green fluorescent protein imaging of tumour growth, metastasis, and
angiogenesis in mouse models. Lancet
Oncology 3, 546-556, 2002.
Sun, F-X., Tohgo, A., Bouvet, M., Yagi,
S., Nassirpour, R., Moossa, A.R., and Hoffman, R.M. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate)
on human pancreatic cancer in an orthotopic metastatic model.
Cancer Research 63, 80-85, 2003.
Wang, J-W., Yang, M., Wang,
X., Sun, F-X., Li, X-M., Yagi, S., and Hoffman, R.M. Antimetastatic efficacy of
oral 5-FU imaged by green fluorescent protein in real time.
Anticancer Research 23, 1-6, 2003.
Yamamoto, N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M. Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases. Clin. Exp. Metastasis 20, 181-185, 2003.[PDF]
John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer Res. 9, 3808-3814, 2003 [PDF].
Glinskii, A.B., Smith, B.A., Jiang, P., Li, X-M., Yang, M., Hoffman, R.M., Glinsky, G.V. Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res. 63, 4239-4243, 2003.[PDF]
Katz, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M., Bouvet, M. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J.Surg. Res. 113, 151-160, 2003.[PDF]
Katz, M.H., Bouvet, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res. 63, 5521-5525, 2003.[PDF]
Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi, V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from non-metastatic breast tumors revealed by labeling with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814, 2003.[PDF]
Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M. Real-time imaging of individual color-coded metastatic colonies in vivo. Clin. Exp. Metastasis 20(7), 633-638, 2003.[PDF]
Yamamoto,
N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and
Hoffman, R.M. Determination of
clonality of metastasis by cell-specific color-coded fluorescent-protein
imaging. Cancer Research 63,
7785-7790, 2003. [PDF]
Mitsiades, C.S., Mitsiades, N.S., Bronson, R.T., Chauhan, D., Munshi, N., Treon, P.S., Maxwell, C.A., Pilarski, L., Hideshima, T., Hoffman,R.M. Fluorescent Imaging of Multiple Myeloma Cells in a Clinically Relevant SCID/NOD in vivo Model: Biological and Clinical Implications. Cancer Research 63, 6689-6696, 2003. [PDF].
Yang,
M., Li, L., Jiang, P., Moossa, A.R., Penman, S., and Hoffman, R.M. Dual-color fluorescence imaging distinguishes tumor cells
from induced host angiogenic vessels and stromal cells. Proc. Natl. Acad. Sci. USA 100,
14259-14262, 2003. [PDF]
Hoffman, R.M., and Yagi, S. In vivo single-cell imaging. Bio-venture (Japan) 3, 77-78, 2003
Katz, M., Spivac, D., Takimoto, S., Bouvet, M., Moosa, A.R., R.M. Hoffman. An imageable highly metastatic orthotopic red fluorescent protein model of pancreatic cancer. Clin. Exp. Metastasis 21, 7-12, 2004.[PDF]
Katz, M.H., Bouvet, M., Takimoto, S., Spivack, D., Moosa, A.R., and Hoffman, R.M. Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Cancer Research 64, 1828-1833, 2004. [PDF]
Furukawa, T., Kubota, T., Watanabe, M.,
Kuo, T.H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K.,
Kitajima, M., and Hoffman, R.M. Immunochemotherapy
prevents human colon cancer metastasis after orthotopic onplantation of
histologically-intact tumor tissue in nude mice.
Anticancer Res. 13, 287-291,
1993.
Furukawa, T., Kubota, T., Watanabe, M.,
Kuo, T-H., Kitajima, M., and Hoffman, R.M.
Differential chemosensitivity of local and metastatic human gastric
cancer after orthotopic transplantation of histologically intact tumor tissue in
nude mice. Int. J. Cancer 54,
397-401, 1993.
Furukawa, T., Kubota, T., Watanabe, M.,
Kitajima, M., and Hoffman, R.M. A
novel "patient-like" treatment model of human pancreatic cancer
constructed using orthotopic transplantation of histologically intact human
tumor tissue in nude mice. Cancer
Res. 53, 3070-3072, 1993.
Kubota, T., Inoue, S., Furukawa, T.,
Ishibiki, K., Kitajima, M., Kawamura, E., and Hoffman, R.M. Similarity of Serum - Tumor Pharmacokinetics of Antitumor
Agents in Man and Nude Mice. Anticancer
Res. 13, 1481-1484, 1993.
Wang, X., Fu, X., Brown, P.D., Crimmin,
M.J., and Hoffman, R.M. Matrix
metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth
and spread in a patient-like orthotopic model in nude mice.
Cancer Res. 54, 4726-4728, 1994.
Murray, G., Duncan, M., O’Neil, P.,
Melvin, W., Fothergill, J. Matrix
metalloproteinase-1 is associated with poor prognosis in colorectal cancer.
Nature Medicine 2, 461-2,
1996.
An, Z., Wang, X., Astoul, P., Danays,
T., Moossa, A.R., and Hoffman, R.M. Interferon
gamma is highly effective against orthotopically-implanted human pleural
adenocarcinoma in nude mice. Anticancer
Res. 16, 2545-2551, 1996.
Olbina, G., Cieslak, D., Ruzdijic, S.,
Esler, C., An, Z., Wang, X., Hoffman, R., Seifert, W., and Pietrzkowski, Z.
Reversible inhibition of IL-8 receptor B mRNA expression and proliferation in
non-small cell lung cancer by antisense oligonucleotides. Anticancer Res. 16,
3525-3530, 1996.
An, Z., Wang, X., Willmott, N., Chander,
S.K., Tickle, S., Docherty, A.J., Mountain, A., Millican, A.T., Morphy, R.,
Porter, J.R., Epemolu, R.O., Kubota, T., Moossa, A.R., and Hoffman, R.M.
Conversion of highly malignant colon cancer from an aggressive to a
controlled disease by oral administration of a metalloproteinase inhibitor.
Clinical & Experimental Metastasis 15,
184-195, 1997.
Inada, T., Ichikawa, A., Kubota, T.,
Ogata, Y., Moossa, A.R., and Hoffman, R.M.
5-FU-induced apoptosis correlates with efficacy against human gastric and
colon cancer xenografts in nude mice. Anticancer
Res. 17, 1965-1971, 1997.
Tomikawa, M., Kubota, T., Matsuzaki,
S.W., Takahasi, S., Kitajima, M., Moossa, A.R., and Hoffman, R.M.
Mitomycin C and cisplatin increase survival in a human pancreatic cancer
metastatic model. Anticancer Res. 17,
3623-3626, 1997.
Chang, S-G., Kim, J.I., Jung, J-C., Rho,
Y-S., Lee, K-T., An, Z., Wang, X., and Hoffman, R.M.
Antimetastatic activity of the new platinum analog {Pt(cis-dach)(DPPE)×2NO3}
in a metastatic model of human bladder cancer.
Anticancer Res. 17, 3239-3242,
1997.
Sasson, A.R., Gamagami, R., An, Z.,
Wang, X., Moossa, A.R., and Hoffman, R.M. Cimetidine:
an inhibitor or promoter of tumor growth? International
Journal of Cancer 81, 835-838, 1999.
Rho, Y-S., Lee, K-T., Jung, J-C, Yoon,
C., An, Z., Hoffman, R.M., and Chang, S-G.
Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of
human colon cancer. Anticancer Res.
19, 157-162, 1999.
Woessner, R., An, Z., Li, X-M.,
Hoffman, R.M., Dix, R., Bitonti, A. Comparison of three approaches to
doxorubicin therapy: free doxorubicin, liposomal doxorubicin, and b-glucuronidase-activated
prodrug (HMR 1826). Anticancer Res.
20, 2289-2296, 2000.
Rashidi, B., An, Z., Sun, F-X., Moossa,
A.R., and Hoffman, R.M. Antimetastatic
intraoperative chemotherapy of human colon tumors in the livers of nude mice.
Clinical Cancer Res. 6,
2464-2468, 2000.
Rashidi, B., An, Z., Sun, F-X, Li, X-M., Tang, Z.Y., Moossa, A.R., and Hoffman, R.M. Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis of human hepatocellular carcinoma in nude mice. Int. J. Cancer 91, 231-235, 2001.[PDF]
Lee, N.C., Bouvet, M., Nardin, S., Jiang, P., Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and Hoffman, R.M. Antimetastatic efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model. Clinical & Experimental Metastasis 18, 379-384, 2001.[PDF]
Hoffman, R.M.
Orthotopic is orthodox: Why are orthotopic-transplant metastatic models
different from all other models? J.
Cellular Biochem. 56, 1-3, 1994.
Hoffman, R.M.
Fertile seed and rich soil: Development of patient-like models of human
cancer by surgical orthotopic implantation of intact tissue.
Update Series: Comprehensive Textbook of Oncology 3, 1-10, Schimpff,
S.C., et al, eds. Williams & Wilkins, Baltimore, 1996.
Hoffman, R.M.
Fertile seed and rich soil: The development of clinically relevant models
of human cancer by surgical orthotopic implantation of intact tissue.
In: Teicher, B., ed. Anticancer
Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval.
Totowa, NJ: Humana Press Inc., 127-144, 1997.
Hoffman, R.M. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Investigational New Drugs 17, 343-359, 1999.[PDF]
Hoffman, R.M. Orthotopic transplant mouse models with green fluorescent protein-expressing cancer cells to visualize metastasis and angiogenesis. Cancer and Metastasis Reviews. 17, 271-277, 1999.[PDF]
Hoffman, R.M.
Clinically Accurate Orthotopic Mouse Models of Cancer.
In: Brooks, S., and Schumacher, U., eds.
Metastasis Research Protocols. Vol. II. Analysis of Cell Behavior In
Vitro and In Vivo.
Totowa, NJ: Humana Press Inc., 251-275, 2001.
Hoffman, R.M.
Green Fluorescent Protein for Metastasis Research.
In: Brooks, S., and Schumacher, U., eds. Metastasis Research Protocols.
Vol. II. Analysis of Cell Behavior In
Vitro and In Vivo. Totowa, NJ:
Humana Press Inc., 285-298, 2001.
Hoffman, R.M.
GFP-Expressing Metastatic-Cancer Mouse Models. In: Teicher, B.,
ed. Tumor Models in Cancer
Research. Totowa, NJ: Humana Press
Inc., 99-112, 2002.
Hoffman, R.M.
Green fluorescent protein imaging of tumor cells in mice.
Lab Animal 31, 34-41, 2002.
Hoffman, R.M.
Watching real-time metastasis in
vivo. Trends in Molecular
Medicine, 8(7), 354-355, 2002.
Hoffman, R.M.
Whole-body fluorescence imaging with Green Fluorescence Protein.
In: Hicks, B.W., ed.
Methods in Molecular Biology, Vol. 183: Green Fluorescent Protein:
Applications and Protocols. Totowa,
NJ: Humana Press, 135-148, 2002.
Hoffman, R.M.
Green fluorescent protein imaging of tumour growth, metastasis, and
angiogenesis in mouse models. Lancet
Oncology 3, 546-556, 2002.
Hoffman, R.M., Orthotopic mouse models of Cancer. In: Anticancer Drug Development Guide Preclinical Screeening, Clinical Trials, and Approval, 2nd Ed., pp. 183-212. Teicher, B., Andrews, P.A., eds. Totowa, NJ: Numana Press, 2004.
Garber, K. Realistic Rodents? Debate grows over new models of cancer. Journal of the National Cancer Institute 98, 1176-1178, 2006.[PDF]