The Leading Metastasis and Angiogenesis Models
Customized service for all your in vivo cancer drug screening, discovery, evaluation and development needs.
Develop New Effective Drugs for Metastasis and Angiogenesis
MetaMouse®/AngioMouse®/OncoBrite®/GeneBrite®
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Green/Red
fluorescent protein (GFP, RFP) tumor expression for quantitative functional
imaging.
• In
vivo drug discovery and evaluation for tumor growth, metastasis,
angiogenesis.
• Whole-body
functional imaging of drug efficacy on tumor growth, metastasis,
angiogenesis, gene expression.
• Real-time
in vivo visualization of tumor growth, metastasis, angiogenesis, gene
expression.
• More than 60
GFP/RFP-expressing tumor models available for MetaMouse®/AngioMouse®.
• Orthotopic
metastatic MetaMouse®/AngioMouse®
models.
• All
types of agents can be evaluated: small molecules, proteins, genes.
• In
vivo high-throughput drug screening and evaluation.
• Customized
contract research for all types of drug discovery and evaluation.
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VIEW WHOLE METAMOUSE POWER POINT PRESENTATION CLICK HERE:
Comparison of GFP and Luciferase Imaging*
| Method | Minimum cells imageable in vitro | Minimum cells imageable in vivo | Need for substrate? | Need for anesthesia? | Method of visualization | Multicolor imaging |
| GFP | 1 | 1 | No | No | Direct Imaging | Yes |
| Luciferase | 300 | 3000 | Yes | Yes | Photon counting (pseudo-color) | No |
* THE LANCET Oncology 3, p546-556, 2002 [PDF]
NEW! METAMOUSE®/ANGIOMOUSE® WHOLE-BODY IMAGING WITH GFP/RFP!
Green/Red Fluorescent Protein to visualize, image and quantify drug efficacy on tumor growth, metastasis, angiogenesis and gene expression in real time.
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| Whole-body imaging of liver metastases in MetaMouse®/OncoBrite® | Skeletal metastases in MetaMouse®/OncoBrite® | Whole-body imaging of tumor angiogenesis in AngioMouse® | Whole-body imaging of single glioma cells in the brain in MetaMouse®/OncoBrite® | Whole-body dual color imaging of GFP and RFP mammary tumors in MetaMouse®/OncoBrite® | Whole-body imaging of gene expression in the liver in GeneBrite® model |
WHOLE-BODY REAL TIME IMAGING OF METASTATIC GROWTH AND DRUG RESPONSE
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DRUG RESPONSE ON HUMAN METASTATIC TUMORS GROWING ORTHOTOPICALLY IN MICE |
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Control |
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Drug Treated | |
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0 | 2 | 4 | 6 | 8 |
Recent MetaMouse®/Oncobrite®/AngioMouse®/GeneBrite® references:
Metamouse® US Patents: 5,491,284; 5,569,812; European Patent 0437488; Japanese Patent 2,664,261. GFP US Patents: 6,232,523; 6,251,384; 6,235,967; 6,235.968; 6,649,159; 6,759,038; 6,905,831; Australian 749,338.
Novel drugs and indications discovered with MetaMouse® and MetaMouse® GFP/RFP models
Organ-specific models-MetaMouse®
Angiogenesis models-AngioMouse®
Molecular Imaging of Chemotherapy