The Leading Metastasis and Angiogenesis Models
The Leading Metastasis and Angiogenesis Models
Customized service for all your in vivo cancer drug screening, discovery, evaluation and development needs.
Develop New Effective Drugs for Metastasis and Angiogenesis
MetaMouse®/AngioMouse®/OncoBrite®/GeneBrite®
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• Green/Red fluorescent protein (GFP, RFP) tumor expression for quantitative functional imaging. • In vivo drug discovery and evaluation for tumor growth, metastasis, angiogenesis. • Whole-body functional imaging of drug efficacy on tumor growth, metastasis, angiogenesis, gene expression. • Real-time in vivo visualization of tumor growth, metastasis, angiogenesis, gene expression. • More than 60 GFP/RFP-expressing tumor models available for MetaMouse®/AngioMouse®. • Orthotopic metastatic MetaMouse®/AngioMouse® models. • All types of agents can be evaluated: small molecules, proteins, genes. • In vivo high-throughput drug screening and evaluation. • Customized contract research for all types of drug discovery and evaluation.
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VIEW WHOLE METAMOUSE PRESENTATION CLICK HERE: 
Comparison of GFP and Luciferase Imaging*
| Method | Minimum cells imageable in vitro | Minimum cells imageable in vivo | Need for substrate? | Need for anesthesia? | Method of visualization | Multicolor imaging |
| GFP | 1 | 1 | No | No | Direct Imaging | Yes |
| Luciferase | 300 | 3000 | Yes | Yes | Photon counting (pseudo-color) | No |
* THE LANCET Oncology 3, p546-556, 2002 [PDF]
NEW! METAMOUSE®/ANGIOMOUSE® WHOLE-BODY IMAGING WITH GFP/RFP!
Green/Red Fluorescent Protein to visualize, image and quantify drug efficacy on tumor growth, metastasis, angiogenesis and gene expression in real time.
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| Whole-body imaging of liver metastases in MetaMouse®/OncoBrite® | Skeletal metastases in MetaMouse®/OncoBrite® | Whole-body imaging of tumor angiogenesis in AngioMouse® | Whole-body imaging of single glioma cells in the brain in MetaMouse®/OncoBrite® | Whole-body dual color imaging of GFP and RFP mammary tumors in MetaMouse®/OncoBrite® | Whole-body imaging of gene expression in the liver in GeneBrite® model |
WHOLE-BODY REAL TIME IMAGING OF METASTATIC GROWTH AND DRUG RESPONSE
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DRUG RESPONSE ON HUMAN METASTATIC TUMORS GROWING ORTHOTOPICALLY IN MICE |
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Drug Treated | |
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0 | 2 | 4 | 6 | 8 |
Recent MetaMouse®/Oncobrite®/AngioMouse®/GeneBrite® references:
MetaMouse US Patents 5,491,284, 5,569,812, Japanese Patents 2,664,261, European Patent 437,488.
GFP US Patents 6,232,523, 6,235,967, 6,235,968, 6,251,384, 6,649,159, 6,759,038, 6,905,831, Japanese Patents 3,709,343 and 4,021,197, European Patents 0979298, 1156833, 1294906,
Australian Patents 749,338 and 2001249297, 2003272221, Chinese Patents 03823937X, German patent 60137501708, Korean Patent 10-868200, Canadian Patents 2,358,439 and 2289283.
NOVEL DRUGS AND INDICATIONS DISCOVERED WITH METAMOUSE® AND METAMAOUSE® GFP/RFP MODELS
ORGAN-SPECIFIC MODELS-METAMOUSE®
ANGIOGENESIS MODELS-ANGIOMOUSE®
MOLECULAR IMAGING OF CHEMOTHERAPY
METAMOUSE® REFERENCES
