The Leading Metastasis and Angiogenesis Models
The Leading Metastasis and Angiogenesis Models
Customized service for all your in vivo cancer drug screening, discovery, evaluation and development needs.
Develop New Effective Drugs for Metastasis and Angiogenesis
MetaMouse®/AngioMouse®/OncoBrite®/GeneBrite®
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Green/Red
fluorescent protein (GFP, RFP) tumor expression for quantitative functional
imaging.
• In
vivo drug discovery and evaluation for tumor growth, metastasis,
angiogenesis.
• Whole-body
functional imaging of drug efficacy on tumor growth, metastasis,
angiogenesis, gene expression.
• Real-time
in vivo visualization of tumor growth, metastasis, angiogenesis, gene
expression.
• More than 60
GFP/RFP-expressing tumor models available for MetaMouse®/AngioMouse®.
• Orthotopic
metastatic MetaMouse®/AngioMouse®
models.
• All
types of agents can be evaluated: small molecules, proteins, genes.
• In
vivo high-throughput drug screening and evaluation.
• Customized
contract research for all types of drug discovery and evaluation.
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VIEW WHOLE METAMOUSE POWER POINT PRESENTATION CLICK HERE:
Comparison of GFP and Luciferase Imaging*
| Method | Minimum cells imageable in vitro | Minimum cells imageable in vivo | Need for substrate? | Need for anesthesia? | Method of visualization | Multicolor imaging |
| GFP | 1 | 1 | No | No | Direct Imaging | Yes |
| Luciferase | 300 | 3000 | Yes | Yes | Photon counting (pseudo-color) | No |
* THE LANCET Oncology 3, p546-556, 2002 [PDF]
NEW! METAMOUSE®/ANGIOMOUSE® WHOLE-BODY IMAGING WITH GFP/RFP!
Green/Red Fluorescent Protein to visualize, image and quantify drug efficacy on tumor growth, metastasis, angiogenesis and gene expression in real time.
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| Whole-body imaging of liver metastases in MetaMouse®/OncoBrite® | Skeletal metastases in MetaMouse®/OncoBrite® | Whole-body imaging of tumor angiogenesis in AngioMouse® | Whole-body imaging of single glioma cells in the brain in MetaMouse®/OncoBrite® | Whole-body dual color imaging of GFP and RFP mammary tumors in MetaMouse®/OncoBrite® | Whole-body imaging of gene expression in the liver in GeneBrite® model |
WHOLE-BODY REAL TIME IMAGING OF METASTATIC GROWTH AND DRUG RESPONSE
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DRUG RESPONSE ON HUMAN METASTATIC TUMORS GROWING ORTHOTOPICALLY IN MICE |
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Control |
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Drug Treated | |
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0 | 2 | 4 | 6 | 8 |
Recent MetaMouse®/Oncobrite®/AngioMouse®/GeneBrite® references:
Metamouse® US Patents: 5,491,284; 5,569,812; European Patent 0437488; Japanese Patent 2,664,261. GFP US Patents: 6,232,523; 6,251,384; 6,235,967; 6,235.968; 6,649,159; 6,759,038; 6,905,831; Australian 749,338.
Novel drugs and indications discovered with MetaMouse® and MetaMouse® GFP/RFP models
Organ-specific models-MetaMouse®
Angiogenesis models-AngioMouse®
Molecular Imaging of Chemotherapy
