Ovarian cancer models

Features

• Orthotopic transplantation of intact tissue

• Metastatic sites

                   peritoneum

                   omentum

                   colon

                   contralateral ovary

                   mesentry

                   lymph nodes

                   subcutaneous tissue

                   liver 

                   pancreas

                   kidney

                   diaphragm 

• Green Fluorescent Protein expression

1.             Fu, X., and Hoffman, R.M.  Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.  Anticancer Res. 13, 283-286, 1993. 

2.             Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M.  Metastatic human pleural ovarian cancer model constructed by orthotopic implantation of fresh histologically-intact patient carcinoma in nude mice.  Anticancer Res. 13, 1999-2002, 1993. 

3.             Kiguchi, K., Kubota, T., Aoki, D., Udagawa, Y., Yamanouchi, S., Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R., and Hoffman, R.M.  A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer. Clinical & Experimental Metastasis 16, 751-756, 1998.