Prostate cancer models 

Features

  • Orthotopic transplantation of intact tissue

  • Metastatic sites

                   lymph nodes

                   liver

                   lung

                   skeleton

  • Green Fluorescent Protein expression

  • Red Fluorescent Protein expression

 

Example

PC-3 human carcinoma growing on prostate and metastasized to numerous lymph nodes of nude mouse. Whole-body image.

1.             Fu, X., Herrera, H., and Hoffman, R.M.  Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue.  Int. J. Cancer 52, 987-990, 1992.

2.             An, Z., Wang, X., Geller, J., Moossa, A.R., and Hoffman, R.M.   Surgical orthotopic implantation allows high lung and lymph node metastatic expression of human prostate carcinoma cell line PC-           3 in nude mice.  The Prostate 34, 169-174, 1998.

3.             Yang, M., Jiang, P., Sun, F.X., Hasegawa, S., Baranov, E., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M.  A fluorescent orthotopic bone metastasis model of human prostate cancer.  Cancer Res. 59, 781-786, 1999.

4.             Wang, X., An, Z., Geller, J., and Hoffman, R.M.  High malignancy orthotopic nude mouse model of human prostate cancer LNCaP.  The Prostate 39, 182-186, 1999.