MetaMouse® Publications:
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General
1.Dutton, G. AntiCancer Inc. scientists identify a
key governing step in the metastasis of cancer. Genetic Engineering
News 16, 1, January 15, 1996. [PDF]
2.Holzman, D. Of mice and metastasis: A new for-profit model
emerges. Journal of the National Cancer Institute 88, 396-397,
1996.[PDF]
3.Riordan, T. A
technique is said to ease attachment of tumors to mice, making them
‘little cancer patients.’ New York Times, “Patents” Column, March 4,
1996. [PDF]
4.Dove, A.
Illuminating cancer models. Nature Biotechnology 18, 261, 2000. [PDF]
5.McCann, J. Jellyfish protein gives new glow to tumor imaging.
Journal of the National Cancer Institute 93, 976-977, 2001[PDF].
Bladder
1.Fu, X., Theodorescu, D., Kerbel, R.S., and
Hoffman, R.M. Extensive multi-organ metastasis following orthotopic
onplantation of histologically-intact human bladder carcinoma tissue
in nude mice. Int. J. Cancer 49, 938-939, 1991.[PDF]
2.Fu, X., and Hoffman, R.M. Human RT-4 bladder carcinoma is highly
metastatic in nude mice and comparable to ras-H-transformed RT-4
when orthotopically onplanted as histologically intact tissue. Int.
J. Cancer 51, 989-991, 1992.[PDF]
3.Chang, S-G.,
Kim, J.I., Jung, J-C., Rho, Y-S., Lee, K-T., An, Z., Wang, X., and
Hoffman, R.M. Antimetastatic activity of the new platinum analog {Pt(cis-dach)(DPPE)×2NO3}
in a metastatic model of human bladder cancer. Anticancer Res. 17,
3239-3242, 1997.[PDF]
4.Zhou, J-H.,
Rosser, C.J., Tanaka, M., Yang, M., Baranov, E., Hoffman, R.M.,
Benedict, W.F. Visualizing superficial human bladder cancer cell
growth in vivo by green fluorescent protein expression. Cancer Gene
Therapy 9, 681-686, 2002. [PDF]
Breast
1.Fu, X., Le, P., and Hoffman, R.M. A metastatic
orthotopic-transplant nude-mouse model of human patient breast
cancer. Anticancer Res. 13, 901-904, 1993. [PDF]
2.Kubota, T., Inoue, S., Furukawa, T., Ishibiki, K., Kitajima, M.,
Kawamura, E., and Hoffman, R.M. Similarity of serum – Tumor
pharmacokinetics of antitumor agents in man and nude mice.
Anticancer Res. 13, 1481-1484, 1993.[PDF]
3.Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang, P., Sun,
F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable metastatic
model of human breast cancer. Clinical & Experimental Metastasis,
19, 347-350, 2002. [PDF]
4.John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis,
G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in
Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer
Res. 9, 3808-3814, 2003 [PDF]
5.Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi,
V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and
site-specific growth potential of cancer cells spontaneously
disseminated from non-metastatic breast tumors revealed by labeling
with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814,
2003. [PDF]
6.Tsuji, K.,
Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y.,
Yamashita, K., Moosa, A.R., and Hoffman, R.M. Dual-color imaging of
nuclear-cytoplasmic dynamics, viability, and proliferation of cancer
cells in portal vein area. Cancer Res. 66, 303-306, 2006.[PDF]
Colon
1.Fu, X., Besterman, J.M., Monosov, A., and Hoffman,
R.M. Models of human metastatic colon cancer in nude mice
orthotopically constructed by using histologically intact patient
specimens. Proc. Natl. Acad. Sci. USA 88, 9345-9349, 1991.[PDF]
2.Fu, X., Herrera, H., Kubota, T., and Hoffman, R.M. Extensive liver
metastasis from human colon cancer in nude and SCID mice after
orthotopic onplantation of histologically-intact human colon
carcinoma tissue. Anticancer Res. 12, 1395-1398, 1992.[PDF]
3.Furukawa, T., Kubota, T., Watanabe, M., Kuo, T.H., Kase, S.,
Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., Kitajima, M.,
and Hoffman, R.M. Immunochemotherapy prevents human colon cancer
metastasis after orthotopic onplantation of histologically-intact
tumor tissue in nude mice. Anticancer Res. 13, 287-291, 1993. [PDF]
4.Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Teramoto,
T., Ishibiki, K., Kitajima, M., and Hoffman, R.M. Early resection of
primary orthotopically-growing human colon tumor in nude mouse
prevents liver metastasis: further evidence for patient-like
hematogenous metastatic route. Anticancer Res. 13, 293-297, 1993. [PDF]
5.Furukawa, T., Kubota, T., Watanabe, M., Kuo, T-H., Nishibori, H.,
Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., and
Kitajima, M. A metastatic model of human colon cancer constructed
using cecal implantation of cancer tissue in nude mice. Jpn. J. Surg.
23, 420-423, 1993. [PDF].
6.Wang, X., Fu, X., Brown, P.D., Crimmin, M.J., and Hoffman, R.M.
Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human
colon tumor growth and spread in a patient-like orthotopic model in
nude mice. Cancer Res. 54, 4726-4728, 1994.. [PDF]
7.Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M.
“Seed” to “soil” is a return trip in metastasis. Anticancer Res. 15,
791-794, 1995.[PDF]
8.Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M.
Host organ specifically determines cancer progression. Cancer Res.
55, 681-684, 1995.[PDF]
9.Kuo, T-H.,
Kubota, T., Watanbe, M., Furukawa, T., Teramoto, T., Ishibiki, K.,
Kitajimi, M., Moossa, A.R., Penman, S., Hoffman, R.M. Liver
colonization competence governs colon cancer metastasis. Proc. Natl.
Acad. Sci. USA 92, 12085-12089, 1995.[PDF]
10.Togo, S., Wang, X., Shimada, H., Moossa, A.R., and Hoffman, R.M.
Cancer seed and soil can be highly selective: Human-patient colon
tumor lung metastasis grows in nude mouse lung but not colon or
subcutis. Anticancer Res. 15, 795-798, 1995.[PDF]
11.Leff, D.N. MetaMouse models colon cancer metastasis with clinical
potential. BioWorld Today 7, 1, January 8, 1996. [PDF]
12.Murray, G., Duncan, M., O’Neil, P., Melvin, W., Fothergill, J.
Matrix metalloproteinase-1 is associated with poor prognosis in
colorectal cancer. Nature Medicine 2, 461-462, 1996. [PDF]
13.An, Z., Wang, X., Willmott, N., Chander, S.K., Tickle, S.,
Docherty, A.J., Mountain, A., Millican, A.T., Morphy, R., Porter,
J.R., Epemolu, R.O., Kubota, T., Moossa, A.R., and Hoffman, R.M.
Conversion of highly malignant colon cancer from an aggressive to a
controlled disease by oral administration of a metalloproteinase
inhibitor. Clinical & Experimental Metastasis 15, 184-195, 1997. [PDF]
14.Sun, F-X., Sasson, A.R., Jiang, P., An, Z., Gamagami, R., Li, L.,
Moossa, A.R., and Hoffman, R.M. An ultra-metastatic model of human
colon cancer in nude mice. Clinical & Experimental Metastasis 17,
41-48, 1999. [PDF]
15.Sasson, A.R., Gamagami, R., An, Z., Wang, X., Moossa, A.R., and
Hoffman, R.M. Cimetidine: An inhibitor or promoter of tumor growth?
International Journal of Cancer 81, 835-838, 1999. [PDF]
16.Rho, Y-S., Lee, K-T., Jung, J-C., Yoon, C., An, Z., Hoffman,
R.M., and Chang, S-G. Efficacy of new platinum analog DPPE in an
orthotopic nude mouse model of human colon cancer. Anticancer Res.
19, 157-162, 1999. [PDF]
17.Rashidi, B., An, Z., Sun, F-X., Sasson, A., Gamagammi, R.,
Moossa, A.R., Hoffman, R.M. Minimal liver resection strongly
stimulates the growth of human colon cancer in the liver of nude
mice. Clinical & Experimental Metastasis 17, 497-500, 1999. [PDF]
18.Rashidi, B., Sun, F-X., Jiang, P., An, Z., Gamagami, R., Moossa,
A.R., and Hoffman, R.M. A nude mouse model of massive liver and
lymph node metastasis of human colon cancer. Anticancer Res. 20,
715-722, 2000. [PDF]
19.Rashidi, B., An, Z., Sun, F-X., Moossa, A.R., and Hoffman, R.M.
Antimetastatic intraoperative chemotherapy of human colon tumors in
the livers of nude mice. Clinical Cancer Res. 6, 2464-2468,
2000.[PDF]
20.Rashidi, B., Gamagami, R., Sasson, A., Sun, F-X., Geller, J.,
Moossa, A.R., and Hoffman, R.M. An orthotopic mouse model of
remetastasis of human colon cancer liver metastasis. Clinical Cancer
Res. 6, 2556-2561, 2000. [PDF]
21.Tsuji, K.,
Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y.,
Yamashita, K., Moosa, A.R., and Hoffman, R.M. Dual-color imaging of
nuclear-cytoplasmic dynamics, viability, and proliferation of cancer
cells in portal vein area. Cancer Res. 66, 303-306, 2006.[PDF]
Gene Therapy
1.Miki, K., Xu, M., An, Z., Wang, X., Yang,
M., Al-Refaie, W., Sun, X., Baranov, E., Tan, Y., Chishima, T.,
Shimada, H., Moossa, A.R., Hoffman, R.M. Survival efficacy of the
combination of the methioninase gene and methioninase in a lung
cancer orthotopic model. Cancer Gene Therapy 7, 332-338, 2000. .
[PDF]
2.Miki, K., Al-Refaie, W., Xu, M., Jiang, P., Tan, Y., Bouvet, M.,
Zhao, M., Gupta, A., Chishima, T., Shimada, H., Makuuchi, M.,
Moossa, A.R., and Hoffman, R.M. Methioninase gene therapy of human
cancer cells is synergistic with recombinant methioninase treatment.
Cancer Res. 60, 2696-2702, 2000.[PDF]
3.Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R.,
Hoffman, R.M. In vivo tumor delivery of the green fluorescent
protein gene to report future occurrence of metastasis. Cancer Gene
Therapy 7, 1336-1340, 2000. [PDF]
4.Djeha, A.H., Thomson, T.A., Leung, H., Searle, P.F., Young, L.S.,
Kerr, D.J., Harris, P.A., Mountain, A., and Wrighton, C.J. Combined
adenovirus-mediated nitroreductase gene delivery and CB1954
treatment: A well-tolerated therapy for established solid tumors.
Molecular Therapy 3, 233-240, 2001. [PDF]
5.Chen, C.T.,
Lin, J., Li, Q., Phipps, S.S., Jakubczak, J.L., Stewart, D.A.,
Skripchenko, Y., Forry-Schaudies, S., Wood, J., Schnell, C., and
Hallenbeck, P.L. Antiangiogenic gene therapy for cancer via systemic
administration of adenoviral vectors expressing secretable
endostatin. Human Gene Therapy 11, 1983-1996, 2000. [PDF]
6.Miki, K, Xu, M., Gupta, A., Ba, Y., Tan, Y., Al-Refaie, W.,
Bouvet, M., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.
Methioninase cancer gene therapy with selenomethionine as suicide
prodrug substrate. Cancer Research 61, 6805-6810, 2001. [PDF]
7.Kamiyama, M.,
Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa, S., Hamaguchi,
Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M., Hyndman, D., Hoffman,
R.M., Ohki, S., and Shimada, H. VEGF receptor antisense therapy
inhibits angiogenesis and peritoneal dissemination of human gastric
cancer in nude mice. Cancer Gene Therapy 9, 197-201, 2002. [PDF]
8.Pirocanac, E.C., Nassirpour, R., Yang, M., Wang, J-W., Nardin,
S.R., Gu, J., Fang, B., Moossa, A.R., Hoffman, R.M., and Bouvet, M.
Bax-induction gene therapy of pancreatic cancer. J. Surg. Res. 106,
346-351, 2002. [PDF]
9.Hoffman, R.M. Immune reactions in skin and hair follicle gene
therapy. Molecular Therapy 7, 294-295, 2003.
10.Katz, M.H.,
Spivak, D.E., Takimoto, S., Fang, B., Burton, D.W., Moosa, A.R.,
Hoffman, R.M., Bouvet, M. Gene Therapy of Pancreatic Cancer With
Green Fluorescent Protein and Tumor Necrosis Factor-Related
Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human
Telomerase Reverse Transcriptase Promoter. Annals of Surgical
Oncology, 10(7): 762-772, 2003. [PDF]
GFP
1.Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H.,
Moossa, A.R., and Hoffman, R.M. Cancer invasion and micrometastasis
visualized in live tissue by green fluorescent protein expression.
Cancer Res. 57, 2042-2047, 1997. [PDF]
2.Chishima, T., Miyagi, Y., Wang, X., Baranov, E., Tan, Y., Shimada,
H., Moossa, A.R., and Hoffman, R.M. Metastatic patterns of lung
cancer visualized live and in process by green fluorescent protein
expression. Clinical & Experimental Metastasis 15, 547-552,
1997.[PDF]
3.Chishima, T., Miyagi, Y., Wang, X., Tan, Y., Shimada, H., Moossa,
A.R., and Hoffman, R.M. Visualization of the metastatic process by
green fluorescent protein expression. Anticancer Res. 17, 2377-2384,
1997. [PDF]
4.Chishima, T., Yang, M., Miyagi, Y., Li, L., Tan, Y., Baranov, E.,
Shimada, H., Moossa, A.R., Penman, S., and Hoffman, R.M. Governing
step of metastasis visualized in vitro. Proc. Natl. Acad. Sci. USA
94, 11573-11576, 1997. [PDF]
5.Chishima, T., Miyagi, Y., Li, L., Tan, Y., Baranov, E., Yang, M.,
Shimada, H., Moossa, A.R., and Hoffman, R.M. The use of histoculture
and green fluorescent protein to visualize tumor cell host
interaction. In Vitro Cell. Dev. Biol. 33, 745-747, 1997. [PDF]
6.Yang, M., Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima,
T., Shimada, H., Moossa, A.R., and Hoffman, R.M. Widespread skeletal
metastatic potential of human lung cancer revealed by green
fluorescent protein expression. Cancer Res. 58, 4217-4221, 1998.
[PDF]
7.Yang, M., Jiang, P., Sun, F.X., Hasegawa, S., Baranov, E.,
Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M. A
fluorescent orthotopic bone metastasis model of human prostate
cancer. Cancer Res. 59, 781-786, 1999.[PDF]
8.Hoffman, R.M. Orthotopic transplant mouse models with green
fluorescent protein-expressing cancer cells to visualize metastasis
and angiogenesis. Cancer and Metastasis Reviews 17, 271-277, 1999.
[PDF]
9.Hoffman, R.M.
Green fluorescent protein to visualize cancer progression and
metastasis. Methods in Enzymology, Green Fluorescent Protein, Vol.
302. Ed: P. Michael Conn, Academic Press, San Diego, pp. 20-31,
1999. [PDF]
10.Naumov, G.N., Wilson, S.M., MacDonald, I.C., Schmidt, E.E.,
Morris, V.L., Groom, A.C., Hoffman, R.M., and Chambers, A.F.
Cellular expression of green fluorescent protein, coupled with
high-resolution in vivo videomicroscopy, to monitor steps in tumor
metastasis. Journal of Cell Science 112, 1835-1842, 1999.
11.Yang, M., Chishima, T., Baranov, E., Shimada, H., Moossa, A.R.,
and Hoffman, R.M. Green fluorescent protein: A new light to
visualize metastasis and angiogenesis in cancer. Proc. of SPIE
Conference on Molecular Imaging: Reporters, Dyes, Markers and
Instrumentation 3500, 117-124, 1999.
12.Yang, M., Jiang, P., An,
Z., Baranov, E., Li, L., Hasegawa, S., Al-Tuwaijri, M., Chishima,
T., Shimada, H., Moossa, A.R., Hoffman, R.M. Genetically fluorescent
melanoma bone and organ metastasis models. Clinical Cancer Res. 5,
3549-3559, 1999. [PDF]
13.Yang, M.,
Chishima, T., Wang, X., Baranov, E., Shimada, H., Moossa, A.R., and
Hoffman, R.M. Multi-organ metastatic capability of Chinese hamster
ovary cells revealed by green fluorescent protein (GFP) expression.
Clinical & Experimental Metastasis, 17, 417-422, 1999.
14.Hoffman, R.M. Visualization of metastasis in orthotopic mouse
models with green fluorescent protein. In: Relevance of Tumor Models
in Anticancer Drugs Development. Eds.: Fiebig, H.H., Burger, A.M.,
Kluwver Academic Publishers, Dordrecht, The Netherlands, Vol. 54,
81-87, 1999.
15.Yang, M., Baranov, E., Jiang, P., Sun, F-X., Li,
X-M., Li, L., Hasegawa, S., Bouvet, M., Al-Tuwaijri, M., Chishima,
T., Shimada, H., Moossa, A.R., Penman, S., Hoffman, R.M. Whole-body
optical imaging of green fluorescent protein-expressing tumors and
metastases. Proc. Natl. Acad. Sci. USA 97, 1206-1211, 2000. [PDF]
16.Dove, A.
Illuminating cancer models. Nature Biotechnology 18, 261, 2000.
17.Hoffman, R.M. Correspondence re: Initial stages of tumor
cell-induced angiogenesis: Evaluation via skin window chambers in
rodent models. Journal of the National Cancer Institute 92, 1445,
2000.
18.Yang, M., Baranov, E., Shimada, H., Moossa, A.R., and
Hoffman, R.M. External optical imaging freely-moving mice with green
fluorescent protein-expressing metastatic tumors. Proc. of SPIE
Conference, 3921, 256-259, 2000.
19.Corrigendum, BioFeedback.
Biotechniques 29, 544, September 2000.
20.Yang, M., Baranov, E.,
Moossa, A.R., Penman, S., Hoffman, R.M. Visualizing gene expression
by whole-body fluorescence imaging. Proc. Natl. Acad. Sci. USA 97,
12278-12282, 2000.[PDF]
21.Hasegawa, S.,
Yang, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M. In
vivo tumor delivery of the green fluorescent protein gene to report
future occurrence of metastasis. Cancer Gene Therapy 7, 1336-1340,
2000. [PDF]
22.Rashidi, B.,
Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X., Moossa, A.R.,
and Hoffman, R.M. A highly metastatic Lewis lung carcinoma
orthotopic green fluorescent protein model. Clinical & Experimental
Metastasis 18, 57-60, 2000. [PDF]
23.Bouvet, M.,
Yang, M., Nardin, S., Wang, X., Jiang, P., Baranov, E., Moossa,
A.R., Hoffman, R.M. Chronologically-specific metastatic targeting of
human pancreatic tumors in orthotopic models. Clinical &
Experimental Metastasis 18, 213-218, 2000.
24.Yang, M., Baranov,
E., Li, X-M., Wang, J-W., Jiang, P., Li, L., Moossa, A.R., Penman,
S., Hoffman, R.M. Whole‑body and intravital optical imaging of
angiogenesis in orthotopically implanted tumors. Proc. Natl. Acad.
Sci. USA 98, 2616-2621, 2001. [PDF]
25.Robinson, K. Imaging system captures whole-body GFP images.
Biophotonics International, April, 54-55, 2001.
26.Pfeifer, A.,
Kessler, T., Yang, M., Baranov, E., Kootstra, N., Cheresh, D.A.,
Hoffman, R.M., and Verma, I.M. Transduction of liver cells by
lentiviral vectors: Analysis in living animals. Molecular Therapy 3,
319-322, 2001.[PDF]
27.Hoffman,
Robert M. Visualization of GFP-expressing tumors and metastasis in
vivo. BioTechniques 30, 1016-1016, 2001.
28.Hutchinson, E.
Fluorescence imaging of tumour metastasis and angiogenesis. The
Lancet Oncology, 2, 254, 2001.
29.McCann, J. Jellyfish protein
gives new glow to tumor imaging. Journal of the National Cancer
Institute 93, 976-977, 2001.
30.Lee, N.C., Bouvet, M., Nardin,
S., Jiang, P., Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa,
A.R., and Hoffman, R.M. Antimetastatic efficacy of adjuvant
gemcitabine in a pancreatic cancer orthotopic model. Clinical &
Experimental Metastasis 18, 379-384, 2001.[PDF]
31.Zhao, M.,
Yang.M., Baranov, E., Wang, X., Penman, S., Moossa, A.R., Hoffman,
R.M. Spatial-temporal imaging of bacterial infection and antibiotic
response in intact animals. Proc. Natl. Acad. Sci. USA 98,
9814-9818, 2001.[PDF]
32.Hoffman, R.M.
Green Fluorescent Protein for Metastasis Research. In: Brooks, S.,
and Schumacher, U., eds. Metastasis Research Protocols. Vol. II.
Analysis of Cell Behavior In Vitro and In Vivo. Totowa, NJ: Humana
Press Inc., 285-298, 2001.
33.Hoffman, R.M. GFP-Expressing
Metastatic-Cancer Mouse Models. In: Teicher, B., ed. Tumor Models in
Cancer Research. Totowa, NJ: Humana Press Inc., 99-112, 2002.
34.Kamiyama, M., Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa,
S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M.,
Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H. VEGF receptor
antisense therapy inhibits angiogenesis and peritoneal dissemination
of human gastric cancer in nude mice. Cancer Gene Therapy 9,
197-201, 2002.
35.Yang, M., Baranov, E., Wang, J-W., Jiang, P.,
Wang, X., Sun, F-X., Bouvet, M., Moossa, A.R., Penman, S., and
Hoffman, R.M. Direct external imaging of nascent cancer, tumor
progression, angiogenesis, and metastasis on internal organs in the
fluorescent orthotopic model. Proc. Natl. Acad. Sci. USA 99,
3824-3829, 2002. [PDF]
36.Bouvet, M.,
Wang, J-W., Nardin, S.R., Nassirpour, R., Yang, M., Baranov, E.,
Jiang, P., Moossa, A.R., and Hoffman, R.M. Real-time optical imaging
of primary tumor growth and multiple metastatic events in a
pancreatic cancer orthotopic model. Cancer Research 62, 1534-1540,
2002. [PDF]
37.Hoffman, R.M. Green fluorescent protein imaging of tumor cells in
mice. Lab Animal 31, 34-41, 2002.
38.Bouvet, M., Nardin, S.R.,
Burton, D.W., Lee, N.C., Yang, M., Wang, X., Baranov, E., Behling,
C., Moossa, A.R., Hoffman, R.M., and Deftos L.J. Parathyroid
hormone-related protein as a novel tumor marker in pancreatic
adenocarcinoma. Pancreas 24, 284-290, 2002.
39.Schmitt, C.A.,
Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M. and Lowe, S.W.
Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1,
289-298, 2002.[PDF]
40.Schmitt, C.A., Yang, M., Fridman, J.S., Baranov, E., Hoffman,
R.M., and Lowe, S.W. Senescence program controlled by p53 and
p16INK4a contributes to the outcome of cancer therapy. Cell 109,
335–346, 2002. [PDF]
41.Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang,
P., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable
metastatic model of human breast cancer. Clinical & Experimental
Metastasis, 19, 347-350, 2002. [PDF]
42.Hoffman, R.M.
Watching real-time metastasis in vivo. Trends in Molecular Medicine,
8(7), 354-355, 2002.
43.Hoffman, R.M. Whole-body fluorescence
imaging with Green Fluorescence Protein. In: Hicks, B.W., ed.
Methods in Molecular Biology, Vol. 183: Green Fluorescent Protein:
Applications and Protocols. Totowa, NJ: Humana Press, 135-148, 2002.
44.Hoffman, R.M. In vivo imaging of metastatic cancer with
fluorescent proteins. Journal of Cell Death and Differentiation 9,
786-789, 2002. [PDF]
45.Zhou, J-H., Rosser, C.J., Tanaka, M., Yang, M., Baranov, E.,
Hoffman, R.M., Benedict, W.F. Visualizing superficial human bladder
cancer cell growth in vivo by green fluorescent protein expression.
Cancer Gene Therapy 9, 681-686, 2002.
46.Hoffman, R.M. Green
fluorescent protein imaging of tumour growth, metastasis, and
angiogenesis in mouse models. Lancet Oncology 3, 546-556, 2002.
[PDF]
47.Saito, N.,
Zhao, M., Li, L., Baranov, E., Yang, M., Ohta, Y., Katsuoka, K.,
Penman, S., and Hoffman, R.M. High efficiency genetic modification
of hair follicles and growing hair shafts. Proc. Natl. Acad. Sci USA
99, 13120-13124, 2002.
48.Sun, F-X., Tohgo, A., Bouvet, M., Yagi,
S., Nassirpour, R., Moossa, A.R., and Hoffman, R.M. Efficacy of
camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic
cancer in an orthotopic metastatic model. Cancer Research 63, 80-85,
2003.[PDF]
49.Wang, J-W.,
Yang, M., Wang, X., Sun, F-X., Li, X-M., Yagi, S., and Hoffman, R.M.
Antimetastatic efficacy of oral 5-FU imaged by green fluorescent
protein in real time. Anticancer Research 23, 1-6, 2003. [PDF]
50.Yamamoto, N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K.,
Moossa, A.R., and Hoffman, R.M. Real-time GFP imaging of spontaneous
HT-1080 fibrosarcoma lung metastases. Clin. Exp. Metastasis 20,
181-185, 2003.[PDF]
51.John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I.,
Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and
Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer.
Clinical Cancer Res. 9, 3808-3814, 2003 [PDF].
52.Glinskii, A.B., Smith, B.A., Jiang, P., Li, X-M., Yang, M.,
Hoffman, R.M., Glinsky, G.V. Viable circulating metastatic cells
produced in orthotopic but not ectopic prostate cancer models.
Cancer Res. 63, 4239-4243, 2003.[PDF]
53.Katz, M.H., Spivack, D.E., Takimoto, S., Fang, B., Burton, D.W.,
Moosa, A.R., Hoffman, R.M., and Bouvet, M. Gene therapy of
pancreatic cancer with green fluorescent protein and tumor necrosis
factor-related apoptosis-inducing ligand fusion gene expression
driven by a human telomerase reverse transcriptase promoter. Annals
of Surgical Oncology 10, 762-772, 2203.
54.Katz, M., Takimoto,
S., Spivac, D., Moossa, A.R., Hoffman, R.M., Bouvet, M. A novel red
fluorescent protein orthotopic pancreatic cancer model for the
preclinical evaluation of chemotherapeutics. J.Surg. Res. 113,
151-160, 2003.[PDF]
55.Katz, M.H., Bouvet, M., Takimoto, S., Spivac, D., Moossa,
A.R., Hoffman, R.M. Selective antimetastatic activity of cytosine
analog CS-682 in a red fluorescent protein orthotopic model of
pancreatic cancer. Cancer Res. 63, 5521-5525, 2003.[PDF]
56.Goodison, S.,
Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi, V., Hoffman,
R.M., and Tarin, D. Prolonged dormancy and site-specific growth
potential of cancer cells spontaneously disseminated from
non-metastatic breast tumors revealed by labeling with green
fluorescent protein. Clinical Cancer Res. 9, 3808-3814, 2003.[PDF]
57.Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H.,
Tomita, K., Moossa, A.R., and Hoffman, R.M. Real-time imaging of
individual color-coded metastatic colonies in vivo. Clin. Exp.
Metastasis 20(7), 633-638, 2003.[PDF]
58.Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H., Tomita,
K., Moossa, A.R., and Hoffman, R.M. Determination of clonality of
metastasis by cell-specific color-coded fluorescent-protein imaging.
Cancer Research 63, 7785-7790, 2003. [PDF]
59.Yang, M., Li,
L., Jiang, P., Moossa, A.R., Penman, S., and Hoffman, R.M.
Dual-color fluorescence imaging distinguishes tumor cells from
induced host angiogenic vessels and stromal cells. Proc. Natl. Acad.
Sci. USA 100, 14259-14262, 2003. [PDF]
60.Hoffman, R.M., and Yagi, S. In vivo single-cell imaging.
Bio-venture (Japan) 3, 77-78, 2003.
61.Mitsiades, C.S.,
Mitsiades, N.S., Bronson, R.T., Chauhan, D., Munshi, N., Treon,
P.S., Maxwell, C.A., Pilarski, L., Hideshima, T., Hoffman,R.M.
Fluorescent Imaging of Multiple Myeloma Cells in a Clinically
Relevant SCID/NOD in vivo Model: Biological and Clinical
Implications. Cancer Research 63, 6689-6696, 2003. [PDF].
62.Katz, M., Spivac, D., Takimoto, S., Bouvet, M., Moosa, A.R., R.M.
Hoffman. An imageable highly metastatic orthotopic red fluorescent
protein model of pancreatic cancer. Clin. Exp. Metastasis 21, 7-12,
2004.[PDF]
63.Katz, M.H., Bouvet, M., Takimoto, S., Spivack, D., Moosa, A.R.,
and Hoffman, R.M. Survival efficacy of adjuvant cytosine-analogue
CS-682 in a fluorescent orthotopic model of human pancreatic cancer.
Cancer Research 64, 1828-1833, 2004. [PDF]
64.Hoffman, R. Multicolor in vivo imaging in mouse models of
cancer. Preclinica. 2, 109-113, 2004. [PDF]
65.Robinson, K. Dual-color fluorescence imaging distinguishes tumor
from host. Biophotonics Intl., January, 56-57, 2004 [PDF]
66.Mihich, E.
and Kaelin, W. Fifteenth Annual Pezcoller Symposium: Molecular in
vivo visualization of cancer cells. Cancer research 64, 2929-2933,
2004 [PDF]
67.Hoffman, R.M. In vivo imaging with fluorescent proteins: The
new cell biology. Acta Histochemica 106, 77-87, 2004. [PDF]
68.Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamauchi, K.,
Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., and Hoffman,
R.M. Cellular dynamics visualized in live cells in vitro and in vivo
by differential dual-color nuclear-cytoplasmic fluorescent-protein
expression. Cancer Research 64, 4251-4256, 2004. [PDF]
69.Yang, M., Amoh, Y., Li, L., Baranov, E., Wang, J-W., Jiang, P.,
Moossa, A.R., and Hoffman, R.M. Dual-color fluorescence imaging of
tumor-host interaction with green and fluorescent proteins. In:
Genetically Engineered and Optical Probes for Biomedical
Applications II (Savitsky, A.P., Brovko, L.Y., Bornhop, D.J.,
Raghavachari, R., Achilefu, S.I., eds). Proceedings of SPIE
Conference, 5329, 54-60, 2004. [PDF]
70.Laakkonen, P., Akerman, M.E., Biliran, H., Yang, M., Ferrer,
F., Karpanen, T., Hoffman, R.M., Ruoslani, E. Antitumor activity of
a homing peptide that targets tumor lymphatics and tumor cells.
Proc. Natl. Acad. Sci. USA 101, 9381-9386, 2004. [PDF]
71.Wang, J-W., Yang, M., Yagi, S., and Hoffman, R.M. Oral 5-FU is a
more effective antimetastatic agent than UFT. Anticancer Research
24, 1353-1360, 2004.
72.Amoh, Y., Li, L., Yang, M., Moosa, A.R.,
Katsuoka, K., Penman, S., and Hoffman, R.M., Nascent blood vessels
in the skin arise from nestin-expressing hair follicle cells. Proc.
Natl. Acad. Sci. USA 101, 13291-13295, 2004. [PDF]
73.Bobek, V. Plachy, J., Pinterova, D., Kolotsova, K., Boubelik, M.,
Jiang, P. P., Yang, M., and Hoffman R. M. Development of a green
fluorescent protein metastatic-cancer chick-embryo drug-screen
model. Clinical & Experimental Metastasis 21, 347-352, 2004. [PDF]
74.Yang, M., Reynoso, J., Jiang, P., Li, L., Moossa, A.R., and
Hoffman, R.M. Transgenic nude mouse with ubiquitous green
fluorescent protein _expression as a host for human tumors. Cancer
Research 64, 8651-8656, 2004. [PDF]
75.Hoffman, R.M. Imaging tumor angiogenesis with fluorescent
proteins. Acta Pathologica, Microbiologica et Immunologica
Scandinavica 112, 441-449, 2004. [PDF]
76.Wang, J., Yang, M., and Hoffman, R.M. Visualizing portal vein
metastatic trafficking to the liver with green fluorescent
protein-expressing tumor cells. Anticancer Research 24,
3699-3702,2004. [PDF]
77.Yamamoto, N., Yang, M., Jiang, P., Xu, M., Yamauchi, K.,
Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M. Color
coding cancer cells with fluorescent proteins to visualize in vivo
cellular interaction in metastatic colonies. Anticancer Research 24,
4067-4072, 2004. [PDF]
78.Bobek, V., Kolostova, K., Pinterov, D., Boubelik, M., Jiang, P.,
Yang, M., and Hoffman, R.M. Syngeneic lymph-node-targeting model of
green fluorescent protein-expressing Lewis lung carcinoma. Clinical
& Experimental Metastasis 21, 705-708, 2004.[PDF]
79.Zhao, M., Yang, M., Li, X-M., Jiang, P., Li, S., Xu, M., and
Hoffman, R.M. Tumor-targeting bacterial therapy with amino acid
auxotrophs of GFP-expressing Salmonella typhimurium. Proc. of Natl.
Acad. Sci USA 102, 755-760, 2005. [PDF]
80.Burton, D.W.,
Geller, J., Yang, M., Jiang, P., Barken, I., Hastings, R.H.,
Hoffman, R.M., and Deftos, L.J. Monitoring of skeletal progression
of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP.
The Prostate 62, 275-281, 2005. DOI: 10.1002/pros.20146. [PDF]
81.Yang, M., Jiang, P., Yamamoto, N., Li, L., Geller, J., Moossa,
A.R., and Hoffman, R.M. Real-time whole-body imaging of an
orthotopic metastatic prostate cancer model expressing rad
fluorescent protein. The Prostate 62, 374-379,2005. DOI
#10.1002/pros.20125. [PDF]
82.Deftos, L.J., Barken, I., Burton, D.W., Hoffman, R.M., and
Geller, J. Direct evidence that PTHrP expression promotes prostate
cancer progression in bone. Biochem. Biophys. Res. Commun. 327,
468-472, 2005. [PDF]
83.Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka,
K., Hoffman, R.M. Hair-follicle-derived blood vessels vascularize
tumors in skin and are inhibited by doxorubicin. Cancer Research 65,
2337-2343, 2005. [PDF]
84.Berezovskaya, O., Schimmer, A.D., Glinskii, A.B., Pinilla,
C., Hoffman, R.M., Reed, J.C., and Glinky, G.V. Increased
_expression of apoptosis inhibitor protein XIAP contributes to
resistance to anoikis of human prostate cancer metastasis precursor
cells. Cancer Research 65, 2378-2386, 2005. [PDF]
85.Amoh, Y., Li, L., Katsuoka, K., Penman, S., and Hoffman, R.M.
Multipotent nestin-positive, keratin-negative hair-follicle-bulge
stem cells can form neurons. Proc. Natl. Acad. Sci. USA 102,
5530-5534, 2005. [PDF]
86.Yamauchi, K., Yang, M., Jiang, P., Yamamoto, N., Xu, M.,
Amoh, Y., Tsuji, K., Bouvet, M., Tsuchiya, H., Tomita, K., Moossa,
A.R., and Hoffman, R.M. Real-time in vivo dual-color imaging of
intracapillary cancer cell and nucleus deformation and migration.
Cancer Res. 65, 4246-4252, 2005. [PDF]
87.Hoffman, R.M. Imaging of angiogenesis in vivo with
fluorescent proteins: fluorescence imaging of angiogenesis. In:
Meadows, Gary G., Ed. Integration/Interaction of Oncologic Growth.
Book Series: Kaiser, H., Ed. Cancer Growth and Progression, 2nd Ed.,
Vol. 15, pp. 37-45. Dordrecht, The Netherlands: Springer, 2005. ISBN
#1-4020-3413-X. [PDF]
88.Amoh, Y.,
Yang, M., Li, L., Reynoso, J., Bouvet, M., Moossa, A.R., Katsuoka,
K., and Hoffman, R.M. Nestin-linked green fluorescent protein
transgenic nude mouse for imaging human tumor angiogenesis. Cancer
Res. 65, 5352-5357, 2005. [PDF]
89.Hoffman, R.M. and Yang, M. Dual-color whole-body imaging in
mice. Nature Biotechnology 23, 790-791, 2005. [PDF]
90.Yang, M., Luiken, G., Baranov, E., and Hoffman, R.M. Facile
whole-body imaging of internal fluorescent tumors in mice with an
LED flashlight. Bio Techniques 39, 170-172, 2005. [PDF]
91.Hoffman, R.M. Advantages of multi-color fluorescent proteins for
whole-body and in in vivo cellular imaging. Journal of Biomedical
Optics 10(4), 41202, AN #041202, 2005. [PDF]
92.Hoffman, R.M. The multiple uses of fluorescent proteins to
visualize cancer in vivo. Nature Reviews Cancer 5, 796-806, 2005.
[PDF]
93.Bouvet, M.,
Spernyak, J., Katz, M.H., Mazurchuk, R.V., Takimoto, S., Bernacki,
R., Rustum, Y.M., Moossa, A.R., and Hoffman, R.M. High correlation
of whole- body red fluorescent protein imaging and magnetic
resonance imaging on an orthotopic model of pancreatic cancer.
Cancer Research 65, 9829-9833, 2005. [PDF]
94.Amoh, Y., Li, L., Campillo, R., Kawahara, K., Katsuoka, K.,
Penman, S., and Hoffman, R.M. Implanted hair follicle stem cells
form Schwann cells that support repair of severed peripheral nerves.
Proc. Natl. Acad. Sci. USA 102, 17734-17738,2005. [PDF]
95.Hoffman, R.M. In vivo cell biology of cancer cells visualized
with fluorescent proteins. In: “In vivo cellular and molecular
imaging” for Current Topics in Developmental Biology, Vol. 70, pp.
121-144. Ahrens, Eric T., ed. London: Elsevier Life Sciences, 2005.
DOI: 10.1016/S0070-2153(05)70006-5. [PDF]
96.Hemman, M.T., Bric, A., Teruya-Feldstein, J., Herbst, A.,
Nilsson, J.A., Cordon-Cardo, C., Cleveland, J.L., Tansey, W.P.,
Lowe, S.W. Evasion of the p53 tumour surveillance network by
tumour-derived MYC mutants. Nature 436, 807-811, 2005. [PDF]
97.Tsuji, K., Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo,
H., Kanai, Y., Yamashita, K., Moossa, A.R., and Hoffman, R.M.
Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and
proliferation of cancer cells in the portal vein area. Cancer Res.
66, 303-306, 2006. [PDF]
Y
98.Pilch, J., Brown, D.M., Komatsu, M., Jarvinen, T., Yang, M.,
Peters, D., Hoffman, R.M., and Ruoslahti, E. Peptides selected for
binding to clotted plasma accumulate in tumor stroma and wounds.
Proc. Natl. Acad. Sci. USA 103, 2800-2804, 2006.
99.Glinsky,
G.V., Glinski, A.B., Berezovskaya, O., Smith, B.A., Jiang, P., Li,
X-M., Yang, M., Hoffman, R.M. Dual color-coded imaging of viable
circulating prostate carcinoma cells reveals genetic exchange
between tumor cells in vivo, contributing to highly metastatic
phenotypes. Cell Cycle 5, 191-197, 2006.
100.Tsuji, K., Yamauchi,
K., Jiang, P., Yang, M., and Hoffman, R.M. Common bile duct
injection as a novel method for establishing RFP-expressing human
pancreatic cancer in nude mice. Journal of the Pancreas 7, 193-199,
2006.
101.Yamauchi, K., Yang, M., Jiang, P., Xu, M., Yamamoto,
N., Tsuchiya, H., Tomita, K., Moosa, A.R., Bouvet, M., and Hoffman,
R.M. Development of real-time subcellular dynamic multicolor imaging
of cancer cell trafficking in live mice with a
variable-magnification whole-mouse imaging system. Cancer Res. 66,
4208-4214, 2006. [PDF]
102.Yang, M., Burton, D.W., Geller, J., Hillegonds, D., Hastings,
R.H., Deftos, L.J., and Hoffman, R.M. The bisphosphanate olpadronate
inhibits skeletal prostate cancer progression in a green fluorescent
protein nude mouse model. Clinical Cancer Research 12, 2602-2606,
2006.
103.Amoh, Y., Li, L., Tsuji, K., Moosa, A.R., Katsuoka, K.,
Hoffman, R.M., Bouvet, M. Dual-color imaging of nascent blood
vessels vascularizing pancreatic cancer in an orthotopic model
demonstrates antioangiogenesis efficacy of gemcitabine. J. Surgical
Research 132, 164-169, 2006.
104.Liu, T., Ding, Y., Xie, W., Li,
Z., Bai, X., Li, X., Fang, W., Ren, C., Wang, S., Hoffman, R.M., and
Yao, K. An imageable metastatic treatment model of nasopharyngeal
carcinoma. Clin. Cancer Res. 13, 3960-3967, 2007.[PDF]
Kidney
1.An, Z., Jiang, P., Wang, X., Moossa, A.R., and
Hoffman, R.M. Development of a high metastatic orthotopic model of
human renal cell carcinoma in nude mice: Benefits of fragment
implantation compared to cell-suspension injection. Clinical &
Experimental Metastasis 17, 265-270, 1999. [PDF]
Liver
1.Sun, F.X., Tang, Z.Y., Liu, K.D., Ye, S.L., Xue,
Q., Gao, D.M., and Ma, Z.C. Establishment of a metastatic model of
human hepatocellular carcinoma in nude mice via orthotopic
implantation of histologically intact tissues. Int. J. Cancer 66,
239-243, 1996. [PDF]
2.Sun, F-X.,
Tang, Z-Y., Liu, K-D., Xue, Q., Gao, D-M., Yu, Y-Q., Zhou, X-D., Ma,
Z-C. Metastatic models of human liver cancer in nude mice
orthotopically constructed by using histologically intact patient
specimens. J. Cancer Res. Clin. Oncol. 122, 397-402, 1996. [PDF]
3.Rashidi, B., An, Z., Sun, F-X, Li, X-M., Tang, Z.Y., Moossa, A.R.,
and Hoffman, R.M. Efficacy of intra-hepatectomy 5-FU on recurrence
and metastasis of human hepatocellular carcinoma in nude mice. Int.
J. Cancer 91, 231-235, 2001. [PDF]
4.Wu, M.,
Mazarchuk, R., Chaudhary, N.D., Spernyak, J., Veith, J., Pera, P.,
Greco, W., Hoffman, R.M., Kobayashi, T., and Bernacki, R.J. High
Resolution Magnetic Resonance Imaging of the Efficacy of the
Cytosine Analogue
1-[2-C-Cyano-2-deoxy-b-D-arabino-pentofuranosyl]-N4 - palmitoyl
Cytosine (CS-682) in a Liver-Metastasis Athymic Nude Mouse Model.
Cancer Res. 63, 2477-2482, 2003. [PDF]
Lung
1.Wang, X., Fu, X., and Hoffman, R.M. A new patient-like metastatic
model of human lung cancer constructed orthotopically with intact
tissue via thoracotomy in immunodeficient mice. Int. J. Cancer 51,
992-995, 1992. [PDF]
2.Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S.,
Tanino, H., Nishibori, K., Saikawa, Y., Teramoto, T., Ishibiki, K.,
Kitajima, M., and Hoffman, R.M. Orthotopic reconstitution of human
small-cell lung carcinoma after intravenous transplantation in SCID
mice. Anticancer Res. 12, 1407-1410, 1992.[PDF]
3.Wang, X., Fu, X., and Hoffman, R.M. A patient-like metastasizing
model of human lung adenocarcinoma constructed via thoracotomy in
nude mice. Anticancer Res. 12, 1399-1402, 1992. [PDF]
4.Wang, X., Fu, X., Kubota, T., and Hoffman, R.M. A new patient-like
metastatic model of human small-cell lung cancer constructed
orthotopically with intact tissue via thoracotomy in nude mice.
Anticancer Res. 12, 1403-1406, 1992. [PDF]
5.Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S.,
Tanino, H., Saikawa, Y., Ishibiki, K., Kitajima, M., and Hoffman,
R.M. Site-specific chemosensitivity of human small-cell lung
carcinoma growing orthotopically compared to subcutaneously in SCID
mice: the importance of orthotopic models to obtain relevant drug
evaluation data. Anticancer Res. 13, 627-630, 1993. [PDF]
6.Astoul, P., Wang, X., and Hoffman, R.M. "Patient-like" nude- and
SCID-mouse models of human lung and pleural cancer (Review). Int. J.
Oncology 3, 713-718, 1993. [PDF]
7.Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M. A
“patient-like” nude mouse model of parietal pleural human lung
adenocarcinoma. Anticancer Res. 14, 85-92, 1994.
8.Astoul, P.,
Colt, H.G., Wang, X., Boutin, C. and Hoffman, R.M. A “patient-like”
nude mouse metastatic model of advanced human pleural cancer.
Journal of Cellular Biochemistry 56, 9-15, 1994.[PDF]
9.Astoul, P., Wang, X., Colt, H.G., Boutin, C., and Hoffman, R.M. A
patient-like human malignant pleural mesothelioma nude-mouse model.
Oncology Reports 3, 483-487, 1996.
10.Colt, H.G., Astoul, P.,
Wang, X., Yi, E.S., Boutin, C., and Hoffman, R.M. Clinical course of
human epithelial-type malignant pleural mesothelioma replicated in
an orthotopic-transplant nude mouse model. Anticancer Res. 16,
633-640, 1996. [PDF]
11.An, Z., Wang, X., Astoul, P., Danays, T., Moossa, A.R., and
Hoffman, R.M. Interferon gamma is highly effective against
orthotopically-implanted human pleural adenocarcinoma in nude mice.
Anticancer Res. 16, 2545-2551, 1996. [PDF]
12.Olbina, G., Cieslak, D., Ruzdijic, S., Esler, C., An, Z., Wang,
X., Hoffman, R., Seifert, W., and Pietrzkowski, Z. Reversible
inhibition of IL-8 receptor B mRNA expression and proliferation in
non-small cell lung cancer by antisense oligonucleotides. Anticancer
Res. 16, 3525-3530, 1996. [PDF]
13.Yang, M., Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima,
T., Shimada, H., Moossa, A.R., and Hoffman, R.M. Widespread skeletal
metastatic potential of human lung cancer revealed by green
fluorescent protein expression. Cancer Res. 58, 4217-4221, 1998.
[PDF]
14.Rashidi, B., Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X.,
Moossa, A.R., and Hoffman, R.M. A highly metastatic Lewis lung
carcinoma orthotopic green fluorescent protein model. Clinical &
Experimental Metastasis 18, 57-60, 2000. [PDF]
15.Hoffman,
Robert M. Metastatic Mouse Models of Lung Cancer. In: Driscoll, B.,
ed. Methods in Molecular Medicine, Vol. 74: Lung Cancer, Vol. 1:
Molecular Pathology Methods and Reviews. Totowa, NJ: Humana Press,
457-464, 2002.. [PDF]
16.Yamamoto, N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K.,
Moossa, A.R., and Hoffman, R.M. Real-time GFP imaging of spontaneous
HT-1080 fibrosarcoma lung metastases. Clin. Exp. Metastasis 20,
181-185, 2003. [PDF]
17.Bobek, V., Boubelik, M., Fiserova, A., L'uptovcova, M.,
Vannucci, L., Kacprzak, G., Kolodzej, J., Majevski, A.M., and
Hoffman R.M. Anticoagulant drugs increase natural killer cell
activity in lung cancer. Lung Cancer 47, 215-223, 2005.
Multiple Myeloma
1.Mitsiades, C.S., Mitsiades, N.S., Bronson,
R.T., Chauhan, D., Munshi, N., Treon, P.S., Maxwell, C.A., Pilarski,
L., Hideshima, T., Hoffman,R.M. Fluorescent Imaging of Multiple
Myeloma Cells in a Clinically Relevant SCID/NOD in vivo Model:
Biological and Clinical Implications. Cancer Research 63, 6689-6696,
2003. [PDF].
2.Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K.,
Hoffman, R.M. Hair-follicle-derived blood vessels vascularize tumors
in skin and are inhibited by doxorubicin. Cancer Research 65,
2337-2343, 2005. [PDF]
Nasopharyngeal Carcinoma
1.Liu, T., Ding, Y., Xie,
W., Li, Z., Bai, X., Li, X., Fang, W., Ren, C., Wang, S., Hoffman,
R.M., and Yao, K. An imageable metastatic treatment model of
nasopharyngeal carcinoma. Clin. Cancer Res. 13, 3960-3967,
2007.[PDF]
Ovarian
1.Fu, X., and Hoffman, R.M. Human ovarian carcinoma metastatic
models constructed in nude mice by orthotopic transplantation of
histologically-intact patient specimens. Anticancer Res. 13,
283-286, 1993.[PDF]
2.Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M. Metastatic
human pleural ovarian cancer model constructed by orthotopic
implantation of fresh histologically-intact patient carcinoma in
nude mice. Anticancer Res. 13, 1999-2002, 1993. [PDF]
3.Kiguchi, K., Kubota, T., Aoki, D., Udagawa, Y., Yamanouchi, S.,
Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R., and Hoffman, R.M. A
patient-like orthotopic implantation nude mouse model of highly
metastatic human ovarian cancer. Clinical & Experimental Metastasis
16, 751-756, 1998. [PDF]
Pancreas
1.Fu, X., Guadagni, F., and Hoffman, R.M. A
metastatic nude-mouse model of human pancreatic cancer constructed
orthotopically from histologically intact patient specimens. Proc.
Natl. Acad. Sci. USA 89, 5645-5649, 1992. [PDF]
2.Furukawa, T.,
Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M. A novel
"patient-like" treatment model of human pancreatic cancer
constructed using orthotopic transplantation of histologically
intact human tumor tissue in nude mice. Cancer Res. 53, 3070-3072,
1993.
3.An, Z., Wang, X., Kubota, T., Moossa, A.R., Hoffman, R.M.
A clinical nude mouse metastatic model for highly malignant human
pancreatic cancer. Anticancer Res. 16, 627-631, 1996.
4.Tomikawa,
M., Kubota, T., Matsuzaki, S.W., Takahasi, S., Kitajima, M., Moossa,
A.R., and Hoffman, R.M. Mitomycin C and cisplatin increase survival
in a human pancreatic cancer metastatic model. Anticancer Res. 17,
3623-3626, 1997.
5.Bouvet, M., Yang, M., Nardin, S., Wang, X.,
Jiang, P., Baranov, E., Moossa, A.R., Hoffman, R.M.
Chronologically-specific metastatic targeting of human pancreatic
tumors in orthotopic models. Clinical & Experimental Metastasis 18,
213-218, 2000.
6.Lee, N.C., Bouvet, M., Nardin, S., Jiang, P.,
Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and
Hoffman, R.M. Antimetastatic efficacy of adjuvant gemcitabine in a
pancreatic cancer orthotopic model. Clinical & Experimental
Metastasis 18, 379-384, 2001.[PDF]
7.Bouvet, M.,
Wang, J-W., Nardin, S.R., Nassirpour, R., Yang, M., Baranov, E.,
Jiang, P., Moossa, A.R., and Hoffman, R.M. Real-time optical imaging
of primary tumor growth and multiple metastatic events in a
pancreatic cancer orthotopic model. Cancer Research 62, 1534-1540,
2002. [PDF]
8.Bouvet, M., Nardin, S.R., Burton, D.W., Lee, N.C., Yang, M., Wang,
X., Baranov, E., Behling, C., Moossa, A.R., Hoffman, R.M., and
Deftos L.J. Parathyroid hormone-related protein as a novel tumor
marker in pancreatic adenocarcinoma. Pancreas 24, 284-290, 2002.
9.Sun, F-X., Tohgo, A., Bouvet, M., Yagi, S., Nassirpour, R.,
Moossa, A.R., and Hoffman, R.M. Efficacy of camptothecin analog
DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an
orthotopic metastatic model. Cancer Research 63, 80-85, 2003. [PDF]
10.Katz, M.,
Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M., Bouvet, M. A
novel red fluorescent protein orthotopic pancreatic cancer model for
the preclinical evaluation of chemotherapeutics. J.Surg. Res. 113,
151-160, 2003.[PDF]
11.Katz, M.H.,
Bouvet, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M.
Selective antimetastatic activity of cytosine analog CS-682 in a red
fluorescent protein orthotopic model of pancreatic cancer. Cancer
Res. 63, 5521-5525, 2003.[PDF]
12.Tsuji, K.,
Yamauchi, K., Jiang, P., Yang, M., and Hoffman, R.M. Common bile
duct injection as a novel method for establishing RFP-expressing
human pancreatic cancer in nude mice. Journal of the Pancreas 7,
193-199, 2006.
13.Katz, M., Spivac, D., Takimoto, S., Bouvet,
M., Moosa, A.R., R.M. Hoffman. An imageable highly metastatic
orthotopic red fluorescent protein model of pancreatic cancer. Clin.
Exp. Metastasis 21, 7-12, 2004.[PDF]
14.Katz, M.H., Bouvet, M., Takimoto, S., Spivack, D., Moosa, A.R.,
and Hoffman, R.M. Survival efficacy of adjuvant cytosine-analogue
CS-682 in a fluorescent orthotopic model of human pancreatic cancer.
Cancer Research 64, 1828-1833, 2004. [PDF]
15.Bouvet, M.,
Spernyak, J., Katz, M.H., Mazurchuk, R.V., Takimoto, S., Bernacki,
R., Rustum, Y.M., Moossa, A.R., and Hoffman, R.M. High correlation
of whole- body red fluorescent protein imaging and magnetic
resonance imaging on an orthotopic model of pancreatic cancer.
Cancer Research 65, 9829-9833, 2005. [PDF]
16.Amoh, Y., Li, L., Tsuji, K., Moosa, A.R., Katsuoka, K., Hoffman,
R.M., Bouvet, M. Dual-color imaging of nascent blood vessels
vascularizing pancreatic cancer in an orthotopic model demonstrates
antioangiogenesis efficacy of gemcitabine. J. Surgical Research 132,
164-169, 2006.
Prostate
1.Fu, X., Herrera, H., and
Hoffman, R.M. Orthotopic growth and metastasis of human prostate
carcinoma in nude mice after transplantation of histologically
intact tissue. Int. J. Cancer 52, 987-990, 1992. [PDF]
2.An, Z., Wang,
X., Geller, J., Moossa, A.R., and Hoffman, R.M. Surgical orthotopic
implantation allows high lung and lymph node metastatic expression
of human prostate carcinoma cell line PC- 3 in nude mice. The
Prostate 34, 169-174, 1998.
3.Yang, M., Jiang, P., Sun, F.X.,
Hasegawa, S., Baranov, E., Chishima, T., Shimada, H., Moossa, A.R.,
and Hoffman, R.M. A fluorescent orthotopic bone metastasis model of
human prostate cancer. Cancer Res. 59, 781-786, 1999. [PDF]
4.Wang, X., An,
Z., Geller, J., and Hoffman, R.M. High malignancy orthotopic nude
mouse model of human prostate cancer LNCaP. The Prostate 39,
182-186, 1999.
5.Glinskii, A.B., Smith, B.A., Jiang, P., Li,
X-M., Yang, M., Hoffman, R.M., Glinsky, G.V. Viable circulating
metastatic cells produced in orthotopic but not ectopic prostate
cancer models. Cancer Res. 63, 4239-4243, 2003.[PDF]
6.Glinsky, G.V.,
Glinskii, A.B., Stephenson A.J., Hoffman, R.M., Gerald W.L. Gene
expression profiling predicts clinical outcome of prostate cancer.
J. Clin. Invest. 113, 913-923, 2004 [PDF]
7.Yang, M., Jiang, P., Yamamoto, N., Li, L., Geller, J., Moossa,
A.R., and Hoffman, R.M. Real-time whole-body imaging of an
orthotopic metastatic prostate cancer model expressing rad
fluorescent protein. The Prostate 62, 374-379,2005. DOI
#10.1002/pros.20125. [PDF]
8.Burton, D.W., Geller, J., Yang, M., Jiang, P., Barken, I.,
Hastings, R.H., Hoffman, R.M., and Deftos, L.J. Monitoring of
skeletal progression of prostate cancer by GFP imaging, X-ray, and
serum OPG and PTHrP. The Prostate 62, 275-281, 2005. DOI:
10.1002/pros.20146. [PDF]
9.Deftos, L.J., Barken, I., Burton, D.W., Hoffman, R.M., and Geller,
J. Direct evidence that PTHrP expression promotes prostate cancer
progression in bone. Biochem. Biophys. Res. Commun. 327, 468-472,
2005. [PDF]
10.Berezovskaya, O., Schimmer, A.D., Glinskii, A.B., Pinilla, C.,
Hoffman, R.M., Reed, J.C., and Glinky, G.V. Increased _expression of
apoptosis inhibitor protein XIAP contributes to resistance to
anoikis of human prostate cancer metastasis precursor cells. Cancer
Research 65, 2378-2386, 2005. [PDF]
11.Glinsky, G.V., Glinski, A.B., Berezovskaya, O., Smith, B.A.,
Jiang, P., Li, X-M., Yang, M., Hoffman, R.M. Dual color-coded
imaging of viable circulating prostate carcinoma cells reveals
genetic exchange between tumor cells in vivo, contributing to highly
metastatic phenotypes. Cell Cycle 5, 191-197, 2006.
Sarcoma
1.Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H.,
Tomita, K., Moossa, A.R., and Hoffman, R.M. Real-time imaging of
individual color-coded metastatic colonies in vivo. Clin. Exp.
Metastasis 20(7), 633-638, 2003.[PDF]
Stomach
1.Furukawa, T., Fu, X., Kubota, T., Watanabe, M., Kitajima, M.,
and Hoffman, R.M. Nude mouse metastatic models of human stomach
cancer constructed using orthotopic implantation of histologically
intact tissue. Cancer Res. 53, 1204-1208, 1993.
2.Furukawa, T.,
Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M. Orthotopic
transplantation of histologically intact clinical specimens of
stomach cancer to nude mice: Correlation of metastatic sites in
mouse and individual patient donors. Int. J. Cancer 53, 608-612,
1993.
3.Furukawa, T., Kubota, T., Watanabe, M., Kuo, T-H.,
Kitajima, M., and Hoffman, R.M. Differential chemosensitivity of
local and metastatic human gastric cancer after orthotopic
transplantation of histologically intact tumor tissue in nude mice.
Int. J. Cancer 54, 397-401, 1993.
4.Inada, T., Ichikawa, A.,
Kubota, T., Ogata, Y., Moossa, A.R., and Hoffman, R.M. 5-FU-induced
apoptosis correlates with efficacy against human gastric and colon
cancer xenografts in nude mice. Anticancer Res. 17, 1965-1971, 1997.
5.Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R.,
Hoffman, R.M. In vivo tumor delivery of the green fluorescent
protein gene to report future occurrence of metastasis. Cancer Gene
Therapy 7, 1336-1340, 2000. [PDF]
6.Kamiyama, M.,
Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa, S., Hamaguchi,
Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M., Hyndman, D., Hoffman,
R.M., Ohki, S., and Shimada, H. VEGF receptor antisense therapy
inhibits angiogenesis and peritoneal dissemination of human gastric
cancer in nude mice. Cancer Gene Therapy 9, 197-201, 2002.
Drug Discovery
1.Furukawa, T., Kubota, T., Watanabe, M., Kuo,
T.H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K.,
Kitajima, M., and Hoffman, R.M. Immunochemotherapy prevents human
colon cancer metastasis after orthotopic onplantation of
histologically-intact tumor tissue in nude mice. Anticancer Res. 13,
287-291, 1993.
2.Furukawa, T., Kubota, T., Watanabe, M., Kuo,
T-H., Kitajima, M., and Hoffman, R.M. Differential chemosensitivity
of local and metastatic human gastric cancer after orthotopic
transplantation of histologically intact tumor tissue in nude mice.
Int. J. Cancer 54, 397-401, 1993.
3.Furukawa, T., Kubota, T.,
Watanabe, M., Kitajima, M., and Hoffman, R.M. A novel "patient-like"
treatment model of human pancreatic cancer constructed using
orthotopic transplantation of histologically intact human tumor
tissue in nude mice. Cancer Res. 53, 3070-3072, 1993.
4.Kubota,
T., Inoue, S., Furukawa, T., Ishibiki, K., Kitajima, M., Kawamura,
E., and Hoffman, R.M. Similarity of Serum - Tumor Pharmacokinetics
of Antitumor Agents in Man and Nude Mice. Anticancer Res. 13,
1481-1484, 1993.
5.Wang, X., Fu, X., Brown, P.D., Crimmin, M.J.,
and Hoffman, R.M. Matrix metalloproteinase inhibitor BB-94
(Batimastat) inhibits human colon tumor growth and spread in a
patient-like orthotopic model in nude mice. Cancer Res. 54,
4726-4728, 1994.
6.Murray, G., Duncan, M., O’Neil, P., Melvin,
W., Fothergill, J. Matrix metalloproteinase-1 is associated with
poor prognosis in colorectal cancer. Nature Medicine 2, 461-2, 1996.
7.An, Z., Wang, X., Astoul, P., Danays, T., Moossa, A.R., and
Hoffman, R.M. Interferon gamma is highly effective against
orthotopically-implanted human pleural adenocarcinoma in nude mice.
Anticancer Res. 16, 2545-2551, 1996.
8.Olbina, G., Cieslak, D.,
Ruzdijic, S., Esler, C., An, Z., Wang, X., Hoffman, R., Seifert, W.,
and Pietrzkowski, Z. Reversible inhibition of IL-8 receptor B mRNA
expression and proliferation in non-small cell lung cancer by
antisense oligonucleotides. Anticancer Res. 16, 3525-3530, 1996.
9.An, Z., Wang, X., Willmott, N., Chander, S.K., Tickle, S.,
Docherty, A.J., Mountain, A., Millican, A.T., Morphy, R., Porter,
J.R., Epemolu, R.O., Kubota, T., Moossa, A.R., and Hoffman, R.M.
Conversion of highly malignant colon cancer from an aggressive to a
controlled disease by oral administration of a metalloproteinase
inhibitor. Clinical & Experimental Metastasis 15, 184-195, 1997.
10.Inada, T., Ichikawa, A., Kubota, T., Ogata, Y., Moossa, A.R., and
Hoffman, R.M. 5-FU-induced apoptosis correlates with efficacy
against human gastric and colon cancer xenografts in nude mice.
Anticancer Res. 17, 1965-1971, 1997.
11.Tomikawa, M., Kubota, T.,
Matsuzaki, S.W., Takahasi, S., Kitajima, M., Moossa, A.R., and
Hoffman, R.M. Mitomycin C and cisplatin increase survival in a human
pancreatic cancer metastatic model. Anticancer Res. 17, 3623-3626,
1997.
12.Chang, S-G., Kim, J.I., Jung, J-C., Rho, Y-S., Lee,
K-T., An, Z., Wang, X., and Hoffman, R.M. Antimetastatic activity of
the new platinum analog {Pt(cis-dach)(DPPE)×2NO3} in a metastatic
model of human bladder cancer. Anticancer Res. 17, 3239-3242, 1997.
13.Sasson, A.R., Gamagami, R., An, Z., Wang, X., Moossa, A.R., and
Hoffman, R.M. Cimetidine: an inhibitor or promoter of tumor growth?
International Journal of Cancer 81, 835-838, 1999.
14.Rho, Y-S.,
Lee, K-T., Jung, J-C, Yoon, C., An, Z., Hoffman, R.M., and Chang,
S-G. Efficacy of new platinum analog DPPE in an orthotopic nude
mouse model of human colon cancer. Anticancer Res. 19, 157-162,
1999.
15.Woessner, R., An, Z., Li, X-M., Hoffman, R.M., Dix, R.,
Bitonti, A. Comparison of three approaches to doxorubicin therapy:
free doxorubicin, liposomal doxorubicin, and
b-glucuronidase-activated prodrug (HMR 1826). Anticancer Res. 20,
2289-2296, 2000.
16.Rashidi, B., An, Z., Sun, F-X., Moossa, A.R.,
and Hoffman, R.M. Antimetastatic intraoperative chemotherapy of
human colon tumors in the livers of nude mice. Clinical Cancer Res.
6, 2464-2468, 2000. [PDF]
17.Rashidi, B.,
An, Z., Sun, F-X, Li, X-M., Tang, Z.Y., Moossa, A.R., and Hoffman,
R.M. Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis
of human hepatocellular carcinoma in nude mice. Int. J. Cancer 91,
231-235, 2001.[PDF]
18.Lee, N.C., Bouvet, M., Nardin, S., Jiang, P., Baranov, E.,
Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and Hoffman, R.M.
Antimetastatic efficacy of adjuvant gemcitabine in a pancreatic
cancer orthotopic model. Clinical & Experimental Metastasis 18,
379-384, 2001.[PDF]
19.Ireson, C.R.,
Chander, S.K., Purohit, A., Perera, S., Newman, S.P., Parish, D.,
Leese, M.P., Smith, A.C., Potter, B.V. and Reed, M.J.
Pharmacokinetics and efficacy of 2-methoxyoestradiol and
2-methoxyoestradiol-bis-sulphamate in vivo rodents. Br. J. Cancer
90, 932-937, 2004.
20.Wang, J-W., Yang, M., Yagi, S., and
Hoffman, R.M. Oral 5-FU is a more effective antimetastatic agent
than UFT. Anticancer Research 24, 1353-1360, 2004.
Reviews
1.Hoffman, R.M. Orthotopic is orthodox: Why are
orthotopic-transplant metastatic models different from all other
models? J. Cellular Biochem. 56, 1-3, 1994.
2.Hoffman, R.M.
Fertile seed and rich soil: Development of patient-like models of
human cancer by surgical orthotopic implantation of intact tissue.
Update Series: Comprehensive Textbook of Oncology 3, 1-10, Schimpff,
S.C., et al, eds. Williams & Wilkins, Baltimore, 1996.
3.Hoffman,
R.M. Fertile seed and rich soil: The development of clinically
relevant models of human cancer by surgical orthotopic implantation
of intact tissue. In: Teicher, B., ed. Anticancer Drug Development
Guide: Preclinical Screening, Clinical Trials, and Approval. Totowa,
NJ: Humana Press Inc., 127-144, 1997.
4.Hoffman, R.M. Orthotopic
metastatic mouse models for anticancer drug discovery and
evaluation: a bridge to the clinic. Investigational New Drugs 17,
343-359, 1999.[PDF]
5.Hoffman, R.M.
Orthotopic transplant mouse models with green fluorescent
protein-expressing cancer cells to visualize metastasis and
angiogenesis. Cancer and Metastasis Reviews. 17, 271-277, 1999.[PDF]
6.Hoffman, R.M.
Clinically Accurate Orthotopic Mouse Models of Cancer. In: Brooks,
S., and Schumacher, U., eds. Metastasis Research Protocols. Vol. II.
Analysis of Cell Behavior In Vitro and In Vivo. Totowa, NJ: Humana
Press Inc., 251-275, 2001.
7.Hoffman, R.M. Green Fluorescent
Protein for Metastasis Research. In: Brooks, S., and Schumacher, U.,
eds. Metastasis Research Protocols. Vol. II. Analysis of Cell
Behavior In Vitro and In Vivo. Totowa, NJ: Humana Press Inc.,
285-298, 2001.
8.Hoffman, R.M. GFP-Expressing Metastatic-Cancer
Mouse Models. In: Teicher, B., ed. Tumor Models in Cancer Research.
Totowa, NJ: Humana Press Inc., 99-112, 2002.
9.Hoffman, R.M.
Green fluorescent protein imaging of tumor cells in mice. Lab Animal
31, 34-41, 2002. metastatic
10.Hoffman, R.M. Watching real-time
metastasis in vivo. Trends in Molecular Medicine, 8(7), 354-355,
2002.
11.Hoffman, R.M. Whole-body fluorescence imaging with Green
Fluorescence Protein. In: Hicks, B.W., ed. Methods in Molecular
Biology, Vol. 183: Green Fluorescent Protein: Applications and
Protocols. Totowa, NJ: Humana Press, 135-148, 2002.
12.Hoffman,
R.M. Green fluorescent protein imaging of tumour growth, metastasis,
and angiogenesis in mouse models. Lancet Oncology 3, 546-556, 2002.
[PDF]
13.Hoffman, R.M.
Orthotopic mouse models of Cancer. In: Anticancer Drug Development
Guide Preclinical Screeening, Clinical Trials, and Approval, 2nd
Ed., pp. 183-212. Teicher, B., Andrews, P.A., eds. Totowa, NJ:
Numana Press, 2004.
14.Glinsky, G.V., Glinskii, A.B., Stephenson
A.J., Hoffman, R.M., Gerald W.L. Gene expression profiling predicts
clinical outcome of prostate cancer. J. Clin. Invest. 113, 913-923,
2004 [PDF]
15.Hoffman, R.M. Orthotopic metastatic (MetaMouse® ) models for
discovery and development of novel chemotherapy. In: Methods in
Molecular Medicine, Vol. III: Chemosensitivity: Vol. II, pp.
297-322, In Vivo Models, Imaging and Molecular Regulators.
Blumenthal, R., ed. ISBN #1-58829-586-9. Totowa, NJ: Humana Press,
2005. DOI #10.1226/1588295869.
16.Hoffman, R.M. Advantages of
multi-color fluorescent proteins for whole-body and in in vivo
cellular imaging. Journal of Biomedical Optics 10(4), 41202, AN
#041202, 2005. [PDF]
17.Hoffman, R.M. In vivo cell biology of cancer cells visualized
with fluorescent proteins. In: “In vivo cellular and molecular
imaging” for Current Topics in Developmental Biology, Vol. 70, pp.
121-144. Ahrens, Eric T., ed. London: Elsevier Life Sciences, 2005.
DOI: 10.1016/S0070-2153(05)70006-5. [PDF]
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